Literature DB >> 7880377

Benzimidazo[1,2-c]quinazolines: a new class of antitumor compounds.

M F Braña1, J M Castellano, G Keilhauer, A Machuca, Y Martín, C Redondo, E Schlick, N Walker.   

Abstract

A series of substituted benzimidazo[1,2-c]quinazolines have been synthesized. This class of compound has been designed by structural comparison with other intercalator patterns. The determination of in vitro activities has shown high inhibitory values.

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Year:  1994        PMID： 7880377

Source DB:  PubMed          Journal:  Anticancer Drug Des        ISSN： 0266-9536


  6 in total

1.  Acid-Catalyzed Synthesis of Isatoic Anhydride-8-Secondary Amides Enables IASA Transformations for Medicinal Chemistry.

Authors:  Sudershan R Gondi; Althaf Shaik; Kenneth D Westover
Journal:  J Org Chem       Date:  2021-12-28       Impact factor: 4.198

2.  Synthesis of novel benzimidazolyl-substituted acrylonitriles and amidino-substituted benzimidazo[1,2-a]quinolines.

Authors:  Marijana Hranjec; Grace Karminski-Zamola
Journal:  Molecules       Date:  2006-08-13       Impact factor: 4.411

3.  5-(4-Methyl-phen-yl)-2,3-diphenyl-5,6-dihydro-imidazo[1,2-c]quinazoline.

Authors:  Jiankang Zhang; Xiaofen Qin; Xingqin Zhou
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-10-09

4.  Synthesis, characterization and in vitro, in vivo, in silico biological evaluations of substituted benzimidazole derivatives.

Authors:  Sabreena Chowdhury Raka; Arifur Rahman; Fahad Hussain; S M Abdur Rahman
Journal:  Saudi J Biol Sci       Date:  2021-08-28       Impact factor: 4.219

5.  Design, synthesis, bio-evaluation, and in silico studies of some N-substituted 6-(chloro/nitro)-1H-benzimidazole derivatives as antimicrobial and anticancer agents.

Authors:  Em Canh Pham; Tuong Vi Thi Le; Tuyen Ngoc Truong
Journal:  RSC Adv       Date:  2022-08-03       Impact factor: 4.036

6.  Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines.

Authors:  Elena A Lyakhova; Yulia A Gusyeva; Julia V Nekhoroshkova; Lev M Shafran; Sergey A Lyakhov
Journal:  Eur J Med Chem       Date:  2009-03-21       Impact factor: 6.514
  6 in total

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