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Literature DB >> 787933

RNA chain elongation on a chromatin template.

Abstract

The rate of RNA chain elongation has been measured with DNA and chromatin as template. RNA propagation on chromatin is about 50% of the rate found with DNA. Kinetic experiments demonstrate that the inhibition is not due to interference with the addition of the nucleoside triphosphates. Analysis of the dependence of propagation on the Tm of DNA shows that the chromatin proteins interfere with the translocation of the RNA polymerase along the DNA template.

Entities: Chemical

Mesh：

Substances：

Year: 1976 PMID： 787933 PMCID： PMC343078 DOI： 10.1093/nar/3.9.2223

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

9 in total

1. Transcription of DNA and chromatin with calf thymus RNA polymerase B in vitro.

Authors: H Cedar
Journal: J Mol Biol Date: 1975-06-25 Impact factor: 5.469

2. The structure of the globin genes in chromatin.

Authors: R Axel; H Cedar; G Felsenfield
Journal: Biochemistry Date: 1975-06-03 Impact factor: 3.162

3. The kinetics of enzyme-catalyzed reactions with two or more substrates or products. III. Prediction of initial velocity and inhibition patterns by inspection.

Authors: W W CLELAND
Journal: Biochim Biophys Acta Date: 1963-02-12

4. The Biology of Isolated Chromatin: Chromosomes, biologically active in the test tube, provide a powerful tool for the study of gene action.

Authors: J Bonner; M E Dahmus; D Fambrough; R C Huang; K Marushige; D Y Tuan
Journal: Science Date: 1968-01-05 Impact factor: 47.728

5 in total

4. Initiation and elongation of polyribonucleotide chains on rat ventral-prostate chromatin transcribed by homologous ribonucleic acid polymerase B.

Authors: P Thomas; P Davies; K Griffiths
Journal: Biochem J Date: 1977-08-15 Impact factor: 3.857

5. Androgenic regulation of elongation of polyribonucleotide chains on rat ventral-prostate chromatin.

Authors: P Thomas; P Davies; K Griffiths
Journal: Biochem J Date: 1978-02-15 Impact factor: 3.857

5 in total

RNA chain elongation on a chromatin template.

1. Transcription of DNA and chromatin with calf thymus RNA polymerase B in vitro.

2. The structure of the globin genes in chromatin.

3. The kinetics of enzyme-catalyzed reactions with two or more substrates or products. III. Prediction of initial velocity and inhibition patterns by inspection.

4. The Biology of Isolated Chromatin: Chromosomes, biologically active in the test tube, provide a powerful tool for the study of gene action.

5. Transcription of the early region of bacteriophage T7: selective initiation with dinucleotides.

6. Mechanism of inhibitory action of histones on DNA template activity in vitro.

7. Kinetics of the in vitro inhibition of transcription by actinomycin.

8. Template activity of partially dehistonized nucleohistones for DNA dependent RNA polymerase.

9. Dependence of the melting temperature of DNA on salt concentration.

1. The sv40 transcription complex. I. Effect of viral chromatin proteins on endogenous RNA polymerase activity.

2. Binding of E. coli RNA polymerase to chromatin subunits.

3. Salt-induced structural changes in nucleosomes.

4. Initiation and elongation of polyribonucleotide chains on rat ventral-prostate chromatin transcribed by homologous ribonucleic acid polymerase B.

5. Androgenic regulation of elongation of polyribonucleotide chains on rat ventral-prostate chromatin.