Literature DB >> 7878020

Biochemical evidence for the autophosphorylation and transphosphorylation of transforming growth factor beta receptor kinases.

F Chen1, R A Weinberg.   

Abstract

Transforming growth factor beta (TGF-beta) signals through a receptor complex containing the type I (TGF-beta RI) and type II (TGF-beta RII) receptors. We describe here biochemical studies on early events in the TGF-beta signaling pathways. TGF-beta RII is highly phosphorylated when expressed alone in COS-1 cells; its autophosphorylation occurs via an intramolecular (cis) mechanism that is independent of ligand binding. TGF-beta RI is also highly phosphorylated when expressed alone in COS-1 cells. Both wild-type TGF-beta RI and a kinase-deficient mutant thereof are transphosphorylated by the coexpressed TGF-beta RII kinase in a ligand-independent fashion in these cells. We propose that the association of TGF-beta RI and TGF-beta RII, induced by ligand binding or over-expression, leads to transphosphorylation of the TGF-beta RI by the TGF-beta RII kinase. This represents a mechanism of activation of receptors distinct from that of tyrosine kinase receptors and may apply to other serine/threonine kinase receptors.

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Year:  1995        PMID： 7878020      PMCID： PMC42560          DOI： 10.1073/pnas.92.5.1565

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  29 in total

1.  Receptors for the TGF-beta superfamily: multiple polypeptides and serine/threonine kinases.

Authors:  H Y Lin; H F Lodish
Journal:  Trends Cell Biol       Date:  1993-01       Impact factor: 20.808

Review 2.  Growth factor signaling by receptor tyrosine kinases.

Authors:  J Schlessinger; A Ullrich
Journal:  Neuron       Date:  1992-09       Impact factor: 17.173

3.  Responsiveness to transforming growth factor-beta (TGF-beta) restored by genetic complementation between cells defective in TGF-beta receptors I and II.

Authors:  M Laiho; F M Weis; F T Boyd; R A Ignotz; J Massagué
Journal:  J Biol Chem       Date:  1991-05-15       Impact factor: 5.157

4.  Homomeric interactions between type II transforming growth factor-beta receptors.

Authors:  R H Chen; R Derynck
Journal:  J Biol Chem       Date:  1994-09-09       Impact factor: 5.157

5.  Transphosphorylation as a possible mechanism for insulin and epidermal growth factor receptor activation.

Authors:  R Lammers; E Van Obberghen; R Ballotti; J Schlessinger; A Ullrich
Journal:  J Biol Chem       Date:  1990-10-05       Impact factor: 5.157

Review 6.  Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta).

Authors:  A B Roberts; M B Sporn
Journal:  Growth Factors       Date:  1993       Impact factor: 2.511

7.  Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme.

Authors:  S Andersson; D L Davis; H Dahlbäck; H Jörnvall; D W Russell
Journal:  J Biol Chem       Date:  1989-05-15       Impact factor: 5.157

8.  Transforming growth factor beta effects on expression of G1 cyclins and cyclin-dependent protein kinases.

Authors:  Y Geng; R A Weinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-01       Impact factor: 11.205

9.  Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation.

Authors:  X Qian; C M LeVea; J K Freeman; W C Dougall; M I Greene
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-15       Impact factor: 11.205

10.  erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells.

Authors:  P P Di Fiore; J H Pierce; M H Kraus; O Segatto; C R King; S A Aaronson
Journal:  Science       Date:  1987-07-10       Impact factor: 47.728
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  26 in total

1.  Internalization-dependent and -independent requirements for transforming growth factor beta receptor signaling via the Smad pathway.

Authors:  Sumedha G Penheiter; Hugh Mitchell; Nandor Garamszegi; Maryanne Edens; Jules J E Doré; Edward B Leof
Journal:  Mol Cell Biol       Date:  2002-07       Impact factor: 4.272

2.  Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation.

Authors:  J J Lebrun; W W Vale
Journal:  Mol Cell Biol       Date:  1997-03       Impact factor: 4.272

3.  Type I (RI) and type II (RII) receptors for transforming growth factor-beta isoforms are expressed subsequent to transforming growth factor-beta ligands during excisional wound repair.

Authors:  L I Gold; J J Sung; J W Siebert; M T Longaker
Journal:  Am J Pathol       Date:  1997-01       Impact factor: 4.307

4.  A novel transforming growth factor-beta receptor-interacting protein that is also a light chain of the motor protein dynein.

Authors:  Qian Tang; Cory M Staub; Guofeng Gao; Qunyan Jin; Zhengke Wang; Wei Ding; Rosemarie E Aurigemma; Kathleen M Mulder
Journal:  Mol Biol Cell       Date:  2002-12       Impact factor: 4.138

5.  Increased histone H1 phosphorylation and relaxed chromatin structure in Rb-deficient fibroblasts.

Authors:  R E Herrera; F Chen; R A Weinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-15       Impact factor: 11.205

6.  Activation of signalling by the activin receptor complex.

Authors:  L Attisano; J L Wrana; E Montalvo; J Massagué
Journal:  Mol Cell Biol       Date:  1996-03       Impact factor: 4.272

7.  SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling.

Authors:  Y Sun; X Liu; E Ng-Eaton; H F Lodish; R A Weinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-26       Impact factor: 11.205

8.  Association of v-ErbA with Smad4 disrupts TGF-beta signaling.

Authors:  Richard A Erickson; Xuedong Liu
Journal:  Mol Biol Cell       Date:  2009-01-14       Impact factor: 4.138

9.  Transforming growth factor-beta type-II receptor signalling: intrinsic/associated casein kinase activity, receptor interactions and functional effects of blocking antibodies.

Authors:  F L Hall; P D Benya; S R Padilla; D Carbonaro-Hall; R Williams; S Buckley; D Warburton
Journal:  Biochem J       Date:  1996-05-15       Impact factor: 3.857

10.  Reconstitution of a pentameric complex of dimeric transforming growth factor beta ligand and a type I, II, III receptor in baculoviral-infected insect cells.

Authors:  K Matsuzaki; M Kan; W L McKeehan
Journal:  In Vitro Cell Dev Biol Anim       Date:  1996-06       Impact factor: 2.416
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