Literature DB >> 7877685

The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins.

G Krapivinsky1, E A Gordon, K Wickman, B Velimirović, L Krapivinsky, D E Clapham.   

Abstract

Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K+) channel, IKACh. Activated muscarinic receptors stimulate IKACh via the G-protein beta gamma-subunits. It has been assumed that the inwardly rectifying K(+)-channel gene, GIRK1, alone encodes IKACh. It is now shown that IKACh is a heteromultimer of two distinct inwardly rectifying K(+)-channel subunits, GIRK1 and a newly cloned member of the family, CIR.

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Year:  1995        PMID： 7877685     DOI： 10.1038/374135a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  249 in total

1.  The inwardly rectifying K(+) channel subunit GIRK1 rescues the GIRK2 weaver phenotype.

Authors:  P Hou; S Yan; W Tang; D J Nelson
Journal:  J Neurosci       Date:  1999-10-01       Impact factor: 6.167

Review 2.  Impact of recent molecular studies on evaluation of ventricular arrhythmias.

Authors:  D M Roden
Journal:  J Interv Card Electrophysiol       Date:  2000-01       Impact factor: 1.900

3.  Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels.

Authors:  P A Slesinger
Journal:  Biophys J       Date:  2001-02       Impact factor: 4.033

4.  Inwardly rectifying K+ channel Kir7.1 is highly expressed in thyroid follicular cells, intestinal epithelial cells and choroid plexus epithelial cells: implication for a functional coupling with Na+,K+-ATPase.

Authors:  N Nakamura; Y Suzuki; H Sakuta; K Ookata; K Kawahara; S Hirose
Journal:  Biochem J       Date:  1999-09-01       Impact factor: 3.857

5.  The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel.

Authors:  J L Leaney; A Tinker
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

6.  Cloning and characterization of G protein-gated inward rectifier K+ channel (GIRK1) isoforms from heart and brain.

Authors:  L Zhu; X Wu; M B Wu; K W Chan; D E Logothetis; W B Thornhill
Journal:  J Mol Neurosci       Date:  2001-02       Impact factor: 3.444

7.  G-protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons.

Authors:  Maria Torrecilla; Cheryl L Marker; Stephanie C Cintora; Markus Stoffel; John T Williams; Kevin Wickman
Journal:  J Neurosci       Date:  2002-06-01       Impact factor: 6.167

8.  Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K+ channels.

Authors:  Amy Benians; Joanne L Leaney; Andrew Tinker
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-28       Impact factor: 11.205

9.  Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir2.1 and Kir2.2.

Authors:  Carsten Zobel; Hee Cheol Cho; The-Tin Nguyen; Roman Pekhletski; Roberto J Diaz; Gregory J Wilson; Peter H Backx
Journal:  J Physiol       Date:  2003-06-06       Impact factor: 5.182

10.  Targeted inactivation of alphai2 or alphai3 disrupts activation of the cardiac muscarinic K+ channel, IK+Ach, in intact cells.

Authors:  M O Sowell; C Ye; D A Ricupero; S Hansen; S J Quinn; P M Vassilev; R M Mortensen
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205
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