Literature DB >> 7874544

Degeneration model of the porcine lumbar motion segment: effects of various intradiscal procedures.

M Pfeiffer1, P Griss, P Franke, C Bornscheuer, J Orth, A Wilke, J D Clausen.   

Abstract

In an experimental study with 18 minipigs, we have tried to establish a model for the standardized evaluation of mechanical, histological and radiological phenomena of degenerative and reparative processes within the lumbar motion segment. Comparing different operative techniques revealed that the intradiscal application of hyaluronic acid into the nuclear defect is likely to enhance the regeneration process. Using the measurement of disc compliance, a semiautomatic picture analyzer and a new semiquantitative disc score could make future studies more comparable. From this basis, the intradiscal application of hyaluronic acid deserves further evaluation.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7874544     DOI： 10.1007/bf02428310

Source DB:  PubMed          Journal:  Eur Spine J        ISSN： 0940-6719            Impact factor:   3.134


  28 in total

1.  1990 Volvo Award in experimental studies. Anulus tears and intervertebral disc degeneration. An experimental study using an animal model.

Authors:  O L Osti; B Vernon-Roberts; R D Fraser
Journal:  Spine (Phila Pa 1976)       Date:  1990-08       Impact factor: 3.468

2.  Experimental incision of the intervertebral disc.

Authors:  J W SMITH; R WALMSLEY
Journal:  J Bone Joint Surg Br       Date:  1951-11

3.  Response of the ligamentous lumbar spine to cyclic bending loads.

Authors:  V K Goel; L M Voo; J N Weinstein; Y K Liu; T Okuma; G O Njus
Journal:  Spine (Phila Pa 1976)       Date:  1988-03       Impact factor: 3.468

4.  Pressure standardized lumbar discography.

Authors:  R C Quinnell; H R Stockdale; B Harmon
Journal:  Br J Radiol       Date:  1980-11       Impact factor: 3.039

5.  Water diffusion pathway, swelling pressure, and biomechanical properties of the intervertebral disc during compression load.

Authors:  H Ohshima; H Tsuji; N Hirano; H Ishihara; Y Katoh; H Yamada
Journal:  Spine (Phila Pa 1976)       Date:  1989-11       Impact factor: 3.468

6.  [Water and electrolyte content of human intervertebral disks under varying load].

Authors:  D Kolditz; J Krämer; R Gowin
Journal:  Z Orthop Ihre Grenzgeb       Date:  1985 Mar-Apr

7.  Changes in endplate vascularity after an outer anulus tear in the sheep.

Authors:  R J Moore; O L Osti; B Vernon-Roberts; R D Fraser
Journal:  Spine (Phila Pa 1976)       Date:  1992-08       Impact factor: 3.468

8.  Studies of the lumbar vertebral end-plate region in the pig.

Authors:  M Törner; S Holm
Journal:  Ups J Med Sci       Date:  1985       Impact factor: 2.384

Review 9.  Secondary structures in hyaluronan solutions: chemical and biological implications.

Authors:  J E Scott
Journal:  Ciba Found Symp       Date:  1989

Review 10.  The specific interaction between fibrin(ogen) and hyaluronan: possible consequences in haemostasis, inflammation and wound healing.

Authors:  P H Weigel; S J Frost; R D LeBoeuf; C T McGary
Journal:  Ciba Found Symp       Date:  1989
View more
  6 in total

1.  Important macroscopic and microscopic differences in the bony and cartilaginous regions adjacent to the lumbar intervertebral disc between animal and man: a caveat to overinterpretation of animal experiments: comment to the article: Primary stability of anterior lumbar stabilization: interdependence of implant type and endplate retention or removal (C.H. Flamme et al.).

Authors:  M Pfeiffer; D Pfeiffer
Journal:  Eur Spine J       Date:  2006-06       Impact factor: 3.134

2.  Injection of a polymerized hyaluronic acid/collagen hydrogel matrix in an in vivo porcine disc degeneration model.

Authors:  G W Omlor; A G Nerlich; H Lorenz; T Bruckner; W Richter; M Pfeiffer; T Gühring
Journal:  Eur Spine J       Date:  2012-04-25       Impact factor: 3.134

3.  Methods to monitor distribution and metabolic activity of mesenchymal stem cells following in vivo injection into nucleotomized porcine intervertebral discs.

Authors:  G W Omlor; H Bertram; K Kleinschmidt; J Fischer; K Brohm; T Guehring; M Anton; Wiltrud Richter
Journal:  Eur Spine J       Date:  2009-12-29       Impact factor: 3.134

4.  A novel in vivo porcine model of intervertebral disc degeneration induced by cryoinjury.

Authors:  Charles-Henri Flouzat-Lachaniette; Nicolas Jullien; Charlie Bouthors; Eric Beohou; Béatrice Laurent; Philippe Bierling; Arnaud Dubory; Hélène Rouard
Journal:  Int Orthop       Date:  2018-05-10       Impact factor: 3.075

5.  Longitudinal Comparison of Enzyme- and Laser-Treated Intervertebral Disc by MRI, X-Ray, and Histological Analyses Reveals Discrepancies in the Progression of Disc Degeneration: A Rabbit Study.

Authors:  Marion Fusellier; Pauline Colombier; Julie Lesoeur; Samy Youl; Stéphane Madec; Olivier Gauthier; Olivier Hamel; Jérôme Guicheux; Johann Clouet
Journal:  Biomed Res Int       Date:  2016-05-10       Impact factor: 3.411

6.  Minimal invasive annulotomy for induction of disc degeneration and implantation of poly (lactic-co-glycolic acid) (PLGA) plugs for annular repair in a rabbit model.

Authors:  Long Xin; Chun Zhang; Fuhua Zhong; Shunwu Fan; Wei Wang; Zhenbin Wang
Journal:  Eur J Med Res       Date:  2016-02-29       Impact factor: 2.175
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.