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Literature DB >> 7873878

Intracisternal A-type particle elements as genetic markers: detection by repeat element viral element amplified locus-PCR.

Abstract

We describe a novel, PCR-based technique termed REVEAL-PCR for examining the inheritance of intracisternal A-type particles (IAP). Amplifications use an unlabeled primer to SINE repeats and a radiolabeled primer to the IAP long terminal repeat; labeled products, which can be resolved on sequencing gels, are formed when IAPs lie in proximity to SINEs. With this technique we have identified a total of 124 polymorphisms in the BXH and CXS recombinant inbred strains. We suggest that this method will be equally applicable for examining other gene families present at around a thousand copies per genome.

Entities: Disease Species

Mesh：

Substances：
Genetic Markers

Year: 1994 PMID： 7873878 DOI： 10.1007/bf00426074

Source DB: PubMed Journal: Mamm Genome ISSN： 0938-8990 Impact factor: 2.957

35 in total

1. A genetic map of the mouse suitable for typing intraspecific crosses.

Authors: W Dietrich; H Katz; S E Lincoln; H S Shin; J Friedman; N C Dracopoli; E S Lander
Journal: Genetics Date: 1992-06 Impact factor: 4.562

2. Genetic and molecular analysis of chlorambucil-induced germ-line mutations in the mouse.

Authors: E M Rinchik; J W Bangham; P R Hunsicker; N L Cacheiro; B S Kwon; I J Jackson; L B Russell
Journal: Proc Natl Acad Sci U S A Date: 1990-02 Impact factor: 11.205

Review 3. The intracisternal A-particle gene family: structure and functional aspects.

Authors: E L Kuff; K K Lueders
Journal: Adv Cancer Res Date: 1988 Impact factor: 6.242

4. Mapping of the motor neuron degeneration (Mnd) gene, a mouse model of amyotrophic lateral sclerosis (ALS).

Authors: A Messer; J Plummer; P Maskin; J M Coffin; W N Frankel
Journal: Genomics Date: 1992-07 Impact factor: 5.736

5. A linkage map of endogenous murine leukemia proviruses.

Authors: W N Frankel; J P Stoye; B A Taylor; J M Coffin
Journal: Genetics Date: 1990-02 Impact factor: 4.562

6. Direct molecular identification of the mouse pink-eyed unstable mutation by genome scanning.

Authors: M H Brilliant; Y Gondo; E M Eicher
Journal: Science Date: 1991-04-26 Impact factor: 47.728

7. Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.

Authors: M Adachi; R Watanabe-Fukunaga; S Nagata
Journal: Proc Natl Acad Sci U S A Date: 1993-03-01 Impact factor: 11.205

8. Inactivation of muscle chloride channel by transposon insertion in myotonic mice.

Authors: K Steinmeyer; R Klocke; C Ortland; M Gronemeier; H Jockusch; S Gründer; T J Jentsch
Journal: Nature Date: 1991-11-28 Impact factor: 49.962

9. Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome.

Authors: N A Jenkins; N G Copeland; B A Taylor; B K Lee
Journal: Nature Date: 1981-10-01 Impact factor: 49.962

6. Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements.

Authors: Ying Zhang; Irina A Maksakova; Liane Gagnier; Louie N van de Lagemaat; Dixie L Mager
Journal: PLoS Genet Date: 2008-02-29 Impact factor: 5.917

6 in total

Intracisternal A-type particle elements as genetic markers: detection by repeat element viral element amplified locus-PCR.

1. A genetic map of the mouse suitable for typing intraspecific crosses.

2. Genetic and molecular analysis of chlorambucil-induced germ-line mutations in the mouse.

Review 3. The intracisternal A-particle gene family: structure and functional aspects.

4. Mapping of the motor neuron degeneration (Mnd) gene, a mouse model of amyotrophic lateral sclerosis (ALS).

5. A linkage map of endogenous murine leukemia proviruses.

6. Direct molecular identification of the mouse pink-eyed unstable mutation by genome scanning.

7. Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.

8. Inactivation of muscle chloride channel by transposon insertion in myotonic mice.

9. Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome.

10. Novel myosin heavy chain encoded by murine dilute coat colour locus.

1. A new spontaneous mouse mutation in the Kcne1 gene.

2. The stumbler mutation maps to proximal mouse chromosome 2.

3. New seizure frequency QTL and the complex genetics of epilepsy in EL mice.

4. Genetic analysis of Gv1, a gene controlling transcription of endogenous murine polytropic proviruses.

5. Genetic map of the region surrounding the retrovirus restriction locus, Fv1, on mouse chromosome 4.

6. Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements.