Literature DB >> 78665

The effect of sodium 5,6-dimethyl-2-nitroindanedione on anaphylactic reactions in vitro.

T J Sharpe, J W Ross, B A Spicer.   

Abstract

A nitroindanedione (BRL 10833) inhibited the antigen induced release of histamine and slow reacting substance of anaphylaxis (SRS-A) from passively sensitized human lung at similar concentrations to those required for the inhibition of histamine release by disodium cromoglycate (DSCG). BRL 10833 was more potent than DSCG as an inhibitor of histamine release by antigen from actively and passively sensitized rat peritoneal cells and rat skin fragments.

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Year:  1978        PMID： 78665     DOI： 10.1007/BF01966603

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  8 in total

1.  An automated fluorimetric assay for the rapid determination of histamine in biological fluids.

Authors:  D P Evans; J A Lewis; D S Thomson
Journal:  Life Sci II       Date:  1973-04-08

2.  Antiallergic activity of 2-nitroindan-1,3-diones.

Authors:  D R Buckle; N J Morgan; J W Ross; H Smith; B A Spicer
Journal:  J Med Chem       Date:  1973-12       Impact factor: 7.446

3.  Procedures for immunochemical study of histamine release from leukocytes with small volume of blood.

Authors:  C D May; M Lyman; R Alberto; J Cheng
Journal:  J Allergy       Date:  1970-07

4.  Disodium cromoglycate. Activity in three in vitro models of the immediate hypersensitivity reaction in lung.

Authors:  P Sheard; A M Blair
Journal:  Int Arch Allergy Appl Immunol       Date:  1970

5.  Interrelationship of cyclic nucleotides and anaphylactic reactions.

Authors:  C J Coulson; R E Ford; S Marshall; J L Walker; K R Wooldridge; K Bowden; T J Coombs
Journal:  Nature       Date:  1977-02-10       Impact factor: 49.962

6.  Inhibition of immediate hypersensitivity reactions in the rat by disodium cromoglycate and nitroindanedione.

Authors:  B A Spicer; J W Ross; H Smith
Journal:  Clin Exp Immunol       Date:  1975-09       Impact factor: 4.330

7.  Increased vascular permeability during passive peritoneal anaphylaxis in the rat. The effects of disodium cromoglycate and a nitroindanedione.

Authors:  J W Ross; H Smith; B A Spicer
Journal:  Int Arch Allergy Appl Immunol       Date:  1976

8.  IgE and IgGa antibody-mediated release of histamine from rat peritoneal cells. I. Optimum conditions for in vitro preparation of target cells with antibody and and challenge with antigen.

Authors:  M K Bach; K J Bloch; K F Austen
Journal:  J Exp Med       Date:  1971-04-01       Impact factor: 14.307
  8 in total
  5 in total

1.  BRL 22321, a compound that has mast cell stabilizing activity similar to that of disodium cromoglycate and in addition has smooth muscle relaxing activity.

Authors:  B A Spicer; J W Ross; G D Clarke; E J Harling; P A Hassall; H Smith; J F Taylor
Journal:  Agents Actions       Date:  1983-06

2.  A comparison of the anti-anaphylactic activities of salbutamol and disodium cromoglycate in the rat, the rat mast cell and in human lung tissue.

Authors:  P R Butchers; J R Fullarton; I F Skidmore; L E Thompson; C J Vardey; A Wheeldon
Journal:  Br J Pharmacol       Date:  1979-09       Impact factor: 8.739

3.  Oxatomide: inhibition and stimulation of histamine release from human lung and leucocytes in vitro.

Authors:  M K Church; C F Gradidge
Journal:  Agents Actions       Date:  1980-04

4.  The activity of sodium cromoglycate analogues in human lung in vitro: a comparison with rat passive cutaneous anaphylaxis and clinical efficacy.

Authors:  M K Church; C F Gradidge
Journal:  Br J Pharmacol       Date:  1980-10       Impact factor: 8.739

5.  The characteristics of inhibition of histamine release from human lung fragments by sodium cromoglycate, salbutamol and chlorpromazine.

Authors:  M K Church; K D Young
Journal:  Br J Pharmacol       Date:  1983-04       Impact factor: 8.739
  5 in total

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