Literature DB >> 7865852

Positive immunostaining for platelet derived growth factor (PDGF) is an adverse prognostic factor in patients with advanced breast cancer.

L Seymour1, W R Bezwoda.   

Abstract

Previous studies suggest a prognostic role for PDGF in patients with breast cancer, with patients with high plasma PDGF levels or positive response to therapy. We have examined a further 58 patients with advanced breast cancer for the presence of tissue PDGF immunostaining. Patients displaying positive tissue immunostaining for PDGF had a highly significant shorter survival (p = 0.002) than patients with no immunostaining. In addition PDGF positive patients treated with combination chemotherapy had a significantly lower response rate (p = 0.05) than PDGF negative patients. These results confirm our previous findings that PDGF may be an important indicator of shortened survival and treatment failure in patients with advanced breast cancer.

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Year:  1994        PMID： 7865852     DOI： 10.1007/bf00665774

Source DB:  PubMed          Journal:  Breast Cancer Res Treat        ISSN： 0167-6806            Impact factor:   4.872


  30 in total

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Journal:  J Biol Chem       Date:  1990-01-25       Impact factor: 5.157

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Journal:  Cancer Res       Date:  1990-02-01       Impact factor: 12.701

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Journal:  Cell Growth Differ       Date:  1991-03

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Journal:  Oncogene       Date:  1992-07       Impact factor: 9.867

8.  Tissue platelet derived-growth factor (PDGF) predicts for shortened survival and treatment failure in advanced breast cancer.

Authors:  L Seymour; D Dajee; W R Bezwoda
Journal:  Breast Cancer Res Treat       Date:  1993       Impact factor: 4.872

9.  Differences in substrate specificities of alpha and beta platelet-derived growth factor (PDGF) receptors. Correlation with their ability to mediate PDGF transforming functions.

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Journal:  J Biol Chem       Date:  1993-05-05       Impact factor: 5.157

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Authors:  A Tingström; C Reuterdahl; P Lindahl; C H Heldin; K Rubin
Journal:  J Immunol       Date:  1992-01-15       Impact factor: 5.422
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  19 in total

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Authors:  Shanchun Guo; Mingli Liu; Ruben R Gonzalez-Perez
Journal:  Biochim Biophys Acta       Date:  2010-12-28

3.  Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity.

Authors:  S Maudsley; A M Zamah; N Rahman; J T Blitzer; L M Luttrell; R J Lefkowitz; R A Hall
Journal:  Mol Cell Biol       Date:  2000-11       Impact factor: 4.272

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Authors:  Martin Jechlinger; Andreas Sommer; Richard Moriggl; Peter Seither; Norbert Kraut; Paola Capodiecci; Michael Donovan; Carlos Cordon-Cardo; Hartmut Beug; Stefan Grünert
Journal:  J Clin Invest       Date:  2006-06       Impact factor: 14.808

5.  Twist1-induced invadopodia formation promotes tumor metastasis.

Authors:  Mark A Eckert; Thinzar M Lwin; Andrew T Chang; Jihoon Kim; Etienne Danis; Lucila Ohno-Machado; Jing Yang
Journal:  Cancer Cell       Date:  2011-03-08       Impact factor: 31.743

6.  An oncogenic activity of PDGF-C and its splice variant in human breast cancer.

Authors:  Alyssa Bottrell; Yong Hong Meng; Abdo J Najy; Newton Hurst; Seongho Kim; Chong Jai Kim; Eun-Sook Kim; Aree Moon; Eun Joo Kim; So Yeon Park; Hyeong-Reh Choi Kim
Journal:  Growth Factors       Date:  2019-09-23       Impact factor: 2.511

7.  In vitro effects of imatinib mesylate on radiosensitivity and chemosensitivity of breast cancer cells.

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Journal:  BMC Cancer       Date:  2010-08-09       Impact factor: 4.430

8.  PDGFRB promotes liver metastasis formation of mesenchymal-like colorectal tumor cells.

Authors:  Ernst J A Steller; Danielle A Raats; Jan Koster; Bert Rutten; Klaas M Govaert; Benjamin L Emmink; Nikol Snoeren; Sander R van Hooff; Frank C P Holstege; Coen Maas; Inne H M Borel Rinkes; Onno Kranenburg
Journal:  Neoplasia       Date:  2013-02       Impact factor: 5.715

9.  A potential oncogenic activity of platelet-derived growth factor d in prostate cancer progression.

Authors:  Carolyn V Ustach; Marcus E Taube; Newton J Hurst; Sunita Bhagat; R Daniel Bonfil; Michael L Cher; Lucia Schuger; Hyeong-Reh Choi Kim
Journal:  Cancer Res       Date:  2004-03-01       Impact factor: 12.701

Review 10.  Regulation of angiogenesis via Notch signaling in breast cancer and cancer stem cells.

Authors:  Weiqiang Zhou; Guangdi Wang; Shanchun Guo
Journal:  Biochim Biophys Acta       Date:  2013-10-30
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