Literature DB >> 7865169

Organization of the human serotonin transporter gene.

K P Lesch1, U Balling, J Gross, K Strauss, B L Wolozin, D L Murphy, P Riederer.   

Abstract

The gene encoding the human serotonin transporter (5-HTT) has been isolated and characterized. The human 5-HTT gene is composed of 14 exons spanning approximately 31 kb. The sequence of all exons including adjacent intronic sequences and a tandem repeat DNA polymorphism (VNTR) has been determined and deposited in the EMBL/GenBank data base with the accession numbers X76753 to X76762. The characterization of 5-HTT gene will aid to advance molecular pharmacologic studies of 5-HT uptake regulation and facilitate investigations of its role in psychiatric disorders.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7865169     DOI： 10.1007/bf01276434

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  20 in total

1.  The presynaptic serotonin uptake site in depression.

Authors:  C B Nemeroff
Journal:  Clin Neuropharmacol       Date:  1992       Impact factor: 1.592

2.  Isolation of cDNAs encoding a novel member of the neurotransmitter transporter gene family.

Authors:  W Mayser; H Betz; P Schloss
Journal:  FEBS Lett       Date:  1991-12-16       Impact factor: 4.124

Review 3.  Genes with triplet repeats: candidate mediators of neuropsychiatric disorders.

Authors:  C A Ross; M G McInnis; R L Margolis; S H Li
Journal:  Trends Neurosci       Date:  1993-07       Impact factor: 13.837

Review 4.  Neurotransmitter transporters: recent progress.

Authors:  S G Amara; M J Kuhar
Journal:  Annu Rev Neurosci       Date:  1993       Impact factor: 12.449

Review 5.  [Neurotransporters : new aspects of the mechanism of action of psychotropic drugs].

Authors:  K P Lesch; H Beckmann
Journal:  Nervenarzt       Date:  1993-01       Impact factor: 1.214

6.  Primary structure of the serotonin transporter in unipolar depression and bipolar disorder.

Authors:  K P Lesch; J Gross; E Franzek; B L Wolozin; P Riederer; D L Murphy
Journal:  Biol Psychiatry       Date:  1995-02-15       Impact factor: 13.382

7.  Cloning and expression of a functional serotonin transporter from rat brain.

Authors:  R D Blakely; H E Berson; R T Fremeau; M G Caron; M M Peek; H K Prince; C C Bradley
Journal:  Nature       Date:  1991-11-07       Impact factor: 49.962

8.  Serotonin uptake in blood platelets of psychiatric patients.

Authors:  H Y Meltzer; R C Arora; R Baber; B J Tricou
Journal:  Arch Gen Psychiatry       Date:  1981-12

9.  Tritiated imipramine binding sites are decreased in the frontal cortex of suicides.

Authors:  M Stanley; J Virgilio; S Gershon
Journal:  Science       Date:  1982-06-18       Impact factor: 47.728

10.  Decreased imipramine binding in the brains of patients with depressive illness.

Authors:  E K Perry; E F Marshall; G Blessed; B E Tomlinson; R H Perry
Journal:  Br J Psychiatry       Date:  1983-02       Impact factor: 9.319
View more
  120 in total

Review 1.  5-hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension.

Authors:  M R MacLean; P Herve; S Eddahibi; S Adnot
Journal:  Br J Pharmacol       Date:  2000-09       Impact factor: 8.739

2.  Enhancement of serotonin uptake by cortisol: a possible link between stress and depression.

Authors:  G E Tafet; M Toister-Achituv; M Shinitzky
Journal:  Cogn Affect Behav Neurosci       Date:  2001-03       Impact factor: 3.282

Review 3.  The role of pharmacogenetics in nonmalignant gastrointestinal diseases.

Authors:  Michael Camilleri
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2012-02-07       Impact factor: 46.802

Review 4.  Is there a genetic contribution to cultural differences? Collectivism, individualism and genetic markers of social sensitivity.

Authors:  Baldwin M Way; Matthew D Lieberman
Journal:  Soc Cogn Affect Neurosci       Date:  2010-06       Impact factor: 3.436

5.  Is 5-HTTLPR linked to the response of selective serotonin reuptake inhibitors in MDD?

Authors:  Ari Illi; Outi Poutanen; Eija Setälä-Soikkeli; Olli Kampman; Merja Viikki; Heini Huhtala; Nina Mononen; Susann Haraldsson; Pasi A Koivisto; Esa Leinonen; Terho Lehtimäki
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2010-07-17       Impact factor: 5.270

Review 6.  A pharmacological analysis of mice with a targeted disruption of the serotonin transporter.

Authors:  Meredith A Fox; Anne M Andrews; Jens R Wendland; Klaus-Peter Lesch; Andrew Holmes; Dennis L Murphy
Journal:  Psychopharmacology (Berl)       Date:  2007-08-22       Impact factor: 4.530

7.  [Serotonin transporter gene and stress reactivity in unipolar depression. Role of the HPA system as endophenotype of the SLC6A4 gene].

Authors:  H Welper; A Aller; V Guttenthaler; S Höfels; L Lennertz; U Pfeiffer; S G Schwab; A Zobel
Journal:  Nervenarzt       Date:  2014-03       Impact factor: 1.214

8.  Metabolic and reproductive consequences of the serotonin transporter promoter polymorphism (5-HTTLPR) in adult female rhesus monkeys (Macaca mulatta).

Authors:  J B Hoffman; J R Kaplan; B Kinkead; S L Berga; M E Wilson
Journal:  Endocrine       Date:  2007-04       Impact factor: 3.633

9.  Triallelic relationships between the serotonin transporter polymorphism and cognition among healthy older adults.

Authors:  Lauren E Salminen; Peter R Schofield; Kerrie D Pierce; Elizabeth M Lane; Jodi M Heaps; Jacob D Bolzenius; Laurie M Baker; Xi Luo; Robert H Paul
Journal:  Int J Neurosci       Date:  2013-10-17       Impact factor: 2.292

10.  The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies.

Authors:  Robert A Philibert; Harinder Sandhu; Nancy Hollenbeck; Tracy Gunter; William Adams; Anup Madan
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2008-07-05       Impact factor: 3.568
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.