Literature DB >> 785980

Suramin stimulates B-lymphocyte proliferation in the mouse.

T L Vischer.   

Abstract

Suramin, a drug against trypanosomiasis and onchocerciasis, stimulates in vitro mouse B-lymphocytes to transform into blastcells, to incorporate 3H-thymidine and to go into mitosis. Thymus cells (hydro-cortisone-sensitive or resistant) do not respond whereas cells from homozygous nude mice are stimulated. The large majority of the blast-cells have surface immunoglobulins, and the proportion of cells with intracellular immunoglobulin increases during the course of the cultures.

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Year:  1976        PMID： 785980     DOI： 10.1007/bf01973263

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  17 in total

1.  Stimulation of mouse B lymphocytes by trypsin.

Authors:  T L Vischer
Journal:  J Immunol       Date:  1974-07       Impact factor: 5.422

2.  Immunoglobulin-like surface molecules and theta antigen during the specific and non-specific stimulation of mouse spleen cells in vitro.

Authors:  T L Vischer
Journal:  Clin Exp Immunol       Date:  1972-08       Impact factor: 4.330

3.  Hypothesis. Bound C3 as the second signal for B-cell activation.

Authors:  P Dukor; K U Hartmann
Journal:  Cell Immunol       Date:  1973-06       Impact factor: 4.868

4.  Mycobacterium tuberculosis in macrophages: effect of certain surfactants and other membrane-active compounds.

Authors:  P D Hart
Journal:  Science       Date:  1968-11-08       Impact factor: 47.728

5.  Evidence for a small pool of immunocompetent cells in the mouse thymus.

Authors:  H Blomgren; B Andersson
Journal:  Exp Cell Res       Date:  1969-10       Impact factor: 3.905

6.  Appearance of hydrolase rich granules in human lymphocytes induced by phytohemagglutinin and antigens.

Authors:  R Hirschhorn; K Hirschhorn; G Weissmann
Journal:  Blood       Date:  1967-07       Impact factor: 22.113

7.  Prolonged C3 depletion by cobra venom factor in thymus-deprived mice and its implication for the role of C3 as an essential second signal for B-cell triggering.

Authors:  J Pryjma; J H Humphrey
Journal:  Immunology       Date:  1975-03       Impact factor: 7.397

8.  Suppression of delayed hypersensitivity in schistosome-infected patients by niridazole.

Authors:  L T Webster; A E Butterworth; A A Mahmoud; E N Mngola; K S Warren
Journal:  N Engl J Med       Date:  1975-05-29       Impact factor: 91.245

9.  Listeria cell wall fraction: a B cell mitogen.

Authors:  J J Cohen; G E Rodriguez; P D Kind; P A Campbell
Journal:  J Immunol       Date:  1975-03       Impact factor: 5.422

10.  Blastic transformtion of mouse spleen lymphocytes by a water-soluble mitogen extracted from Nocardia.

Authors:  C Bona; C Damais; L Chedid
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205
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  4 in total

1.  Suramin stimulates renal growth in the rat.

Authors:  L Selmeci; K Szepesházi; E Pósch; L Hársing
Journal:  Experientia       Date:  1978-02-15

2.  Induction of proteolytic activity in serum by treatment with anionic detergents and organic solvents.

Authors:  D Berger; T L Vischer; A Micheli
Journal:  Experientia       Date:  1983-10-15

3.  Suramin inhibits tumor cell cytotoxicity mediated through natural killer cells, lymphokine-activated killer cells, monocytes, and tumor necrosis factor.

Authors:  R LaPushin; K Totpal; M Higuchi; B B Aggarwal
Journal:  J Clin Immunol       Date:  1994-01       Impact factor: 8.317

4.  In vitro stimulation of lymphocytes by neutral proteinases from human polymorphonuclear leukocyte granules.

Authors:  T L Vischer; U Bretz; M Baggiolini
Journal:  J Exp Med       Date:  1976-10-01       Impact factor: 14.307
  4 in total

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