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Literature DB >> 7855896

The multifunctional TFIIH complex and transcriptional control.

Abstract

RNA polymerase II (Pol II) requires seven general transcription factors (GTFs) and ATP for transcription initiation. Transcription factor IIH (TFIIH) has emerged as the sole GTF with enzymatic activity. In addition to its essential role in transcription initiation, recent studies have demonstrated a direct involvement of TFIIH in DNA excision repair processes. The enzymatic properties and functional duality of TFIIH make it a prime target for regulation by viral and cellular factors.

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Year: 1994 PMID： 7855896 DOI： 10.1016/0968-0004(94)90139-2

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

34 in total

1. hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation.

Authors: M K Kim; V M Nikodem
Journal: Mol Cell Biol Date: 1999-10 Impact factor: 4.272

2. The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes.

Authors: Q Feng; Y Zhang
Journal: Genes Dev Date: 2001-04-01 Impact factor: 11.361

3. Reduced RNA polymerase II transcription in extracts of cockayne syndrome and xeroderma pigmentosum/Cockayne syndrome cells.

Authors: G L Dianov; J F Houle; N Iyer; V A Bohr; E C Friedberg
Journal: Nucleic Acids Res Date: 1997-09-15 Impact factor: 16.971

10. Promoter-proximal stalling results from the inability to recruit transcription factor IIH to the transcription complex and is a regulated event.

Authors: K P Kumar; S Akoulitchev; D Reinberg
Journal: Proc Natl Acad Sci U S A Date: 1998-08-18 Impact factor: 11.205

The multifunctional TFIIH complex and transcriptional control.

1. hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation.

2. The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes.

3. Reduced RNA polymerase II transcription in extracts of cockayne syndrome and xeroderma pigmentosum/Cockayne syndrome cells.

4. Genetic analysis of the large subunit of yeast transcription factor IIE reveals two regions with distinct functions.

5. Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH.

6. Human cyclin-dependent kinase-activating kinase exists in three distinct complexes.

Review 7. Cockayne syndrome: defective repair of transcription?

Review 8. DNA replication, RNAi and epigenetic inheritance.

9. The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7.

10. Promoter-proximal stalling results from the inability to recruit transcription factor IIH to the transcription complex and is a regulated event.