Literature DB >> 7855602

Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line.

S P Lees-Miller1, R Godbout, D W Chan, M Weinfeld, R S Day, G M Barron, J Allalunis-Turner.   

Abstract

The radiosensitive rodent mutant cell line xrs-5 is defective in DNA double-strand break repair and lacks the Ku component of the DNA-activated protein kinase, DNA-PK. Here radiosensitive human cell lines were analyzed for DNA-PK activity and for the presence of related proteins. The radiosensitive human malignant glioma M059J cell line was found to be defective in DNA double-strand break repair, but fails to express the p350 subunit of DNA-PK. These results suggest that DNA-PK kinase activity is involved in DNA double-strand break repair.

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Year:  1995        PMID： 7855602     DOI： 10.1126/science.7855602

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  164 in total

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Authors:  G S Brush; D M Clifford; S M Marinco; A J Bartrand
Journal:  Nucleic Acids Res       Date:  2001-12-01       Impact factor: 16.971

2.  BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair.

Authors:  Ismail Hassan Ismail; Christi Andrin; Darin McDonald; Michael J Hendzel
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3.  UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein.

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4.  Subnuclear localization of Ku protein: functional association with RNA polymerase II elongation sites.

Authors:  Xianming Mo; William S Dynan
Journal:  Mol Cell Biol       Date:  2002-11       Impact factor: 4.272

5.  Biochemical evidence for Ku-independent backup pathways of NHEJ.

Authors:  Huichen Wang; Ange Ronel Perrault; Yoshihiko Takeda; Wei Qin; Hongyan Wang; George Iliakis
Journal:  Nucleic Acids Res       Date:  2003-09-15       Impact factor: 16.971

6.  Diverse roles for E4orf3 at late times of infection revealed in an E1B 55-kilodalton protein mutant background.

Authors:  Robin N Shepard; David A Ornelles
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

7.  Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.

Authors:  Xiaoshan Zhang; Janice Succi; Zhaohui Feng; Sheela Prithivirajsingh; Michael D Story; Randy J Legerski
Journal:  Mol Cell Biol       Date:  2004-10       Impact factor: 4.272

8.  Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks.

Authors:  Doug W Chan; Benjamin Ping-Chi Chen; Sheela Prithivirajsingh; Akihiro Kurimasa; Michael D Story; Jun Qin; David J Chen
Journal:  Genes Dev       Date:  2002-09-15       Impact factor: 11.361

9.  DNA-PK-dependent binding of DNA ends to plasmids containing nuclear matrix attachment region DNA sequences: evidence for assembly of a repair complex.

Authors:  Stanley K Mauldin; Robert C Getts; Wenjing Liu; Thomas D Stamato
Journal:  Nucleic Acids Res       Date:  2002-09-15       Impact factor: 16.971

Review 10.  Non-homologous end joining: emerging themes and unanswered questions.

Authors:  Sarvan Kumar Radhakrishnan; Nicholas Jette; Susan P Lees-Miller
Journal:  DNA Repair (Amst)       Date:  2014-02-26
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