Literature DB >> 785224

Genetics of borrelidin resistant mutants of Saccharomyces cerivisiae and properties of their threonyl-tRNA-synthetase.

G Nass, K Poralla.   

Abstract

Twenty-two borrelidin resistant mutants of Saccharomyces cerivisiae were isolated, studied genetically and their threonyl-tRNA-synthetase was investigated. The borrelidin resistant mutants are classified into four groups. In the first group borrelidin resistance is coupled to the gene HOM3 coding for aspartokinase, in the second group to the gene LEU1. The borrelidin resistance in group three and four is not coupled to anyone of the genetic markers tested. Borrelidin resistance exhibited dominant behavior in all mutants except in the mutant of group 4. The properties of the ThrRS of the mutants of group one, two and four was found to be like the ones of the wild types. However the mutants of group three exhibit a structurally altered ThrRS, which is no longer inhibited by borrelidin.

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Year:  1976        PMID： 785224     DOI： 10.1007/bf00337933

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  13 in total

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Authors:  F C Neihardt; J Parker; W G McKeever
Journal:  Annu Rev Microbiol       Date:  1975       Impact factor: 15.500

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3.  The Detection of Linkage in Tetrad Analysis.

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Authors:  W Paetz; G Nass
Journal:  Eur J Biochem       Date:  1973-06

5.  Alteration of structure of level of threonyl-tRNA-synthetase in Borrelidin resistant mutants of E. coli.

Authors:  G Nass; J Thomale
Journal:  FEBS Lett       Date:  1974-02-15       Impact factor: 4.124

6.  [Metabolic products of microorganisms. 5l. On the mechanism of action of borrelidin-inhibition of the threonine incorporation in sRNA].

Authors:  R Hütter; K Poralla; H G Zachau; H Zähner
Journal:  Biochem Z       Date:  1966-03-28

7.  Regulation of histidine biosynthetic enzymes in a mutant of Escherichia coli with an altered histidyl-tRNA synthetase.

Authors:  G Nass
Journal:  Mol Gen Genet       Date:  1967

8.  A mutant of yeast with a defective methionyl-tRNA synthetase.

Authors:  C S McLaughlin; L H Hartwell
Journal:  Genetics       Date:  1969-03       Impact factor: 4.562

9.  Multiplicity of the amino acid permeases in Saccharomyces cerevisiae. I. Evidence for a specific arginine-transporting system.

Authors:  M Grenson; M Mousset; J M Wiame; J Bechet
Journal:  Biochim Biophys Acta       Date:  1966-10-31

10.  Relationship between methionyl transfer ribonucleic acid cellular content and synthesis of methionine enzymes in Saccharomyces cerevisiae.

Authors:  Y Surdin-Kerjan; H Cherest; H Robichon-Szulmajster
Journal:  J Bacteriol       Date:  1973-03       Impact factor: 3.490
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  11 in total

Review 1.  Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics.

Authors:  Christopher S Francklyn; Patrick Mullen
Journal:  J Biol Chem       Date:  2019-01-22       Impact factor: 5.157

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Authors:  R K Mortimer; D Schild
Journal:  Microbiol Rev       Date:  1985-09

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Authors:  L K Pape; A Tzagoloff
Journal:  Nucleic Acids Res       Date:  1985-09-11       Impact factor: 16.971

4.  Homoserine and threonine pools of borrelidin resistant Saccharomyces cerevisiae mutants with an altered aspartokinase.

Authors:  M Seibold; K Nill; K Poralla
Journal:  Arch Microbiol       Date:  1981-07       Impact factor: 2.552

5.  Genetic map of Saccharomyces cerevisiae.

Authors:  R K Mortimer; D Schild
Journal:  Microbiol Rev       Date:  1980-12

6.  Genetic mapping of nuclear mucidin resistance mutations in Saccharomyces cerevisiae. A new pdr locus on chromosome II.

Authors:  J Subik; S Ulaszewski; A Goffeau
Journal:  Curr Genet       Date:  1986       Impact factor: 3.886

7.  Overproduction of threonine by Saccharomyces cerevisiae mutants resistant to hydroxynorvaline.

Authors:  C Ramos; I L Calderon
Journal:  Appl Environ Microbiol       Date:  1992-05       Impact factor: 4.792

8.  Identification of a glutaminyl-tRNA synthetase mutation Saccharomyces cerevisiae.

Authors:  A P Mitchell; S W Ludmerer
Journal:  J Bacteriol       Date:  1984-05       Impact factor: 3.490

9.  Interaction of the yeast pleiotropic drug resistance genes PDR1 and PDR5.

Authors:  S Meyers; W Schauer; E Balzi; M Wagner; A Goffeau; J Golin
Journal:  Curr Genet       Date:  1992-05       Impact factor: 3.886

10.  Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor.

Authors:  Adam C Mirando; Pengfei Fang; Tamara F Williams; Linda C Baldor; Alan K Howe; Alicia M Ebert; Barrie Wilkinson; Karen M Lounsbury; Min Guo; Christopher S Francklyn
Journal:  Sci Rep       Date:  2015-08-14       Impact factor: 4.379
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