Literature DB >> 7851878

Cloning the human major histocompatibility complex in YACs.

H Abderrahim1, J L Sambucy, F Iris, P Ougen, A Billault, I M Chumakov, J Dausset, D Cohen, D Le Paslier.   

Abstract

To clone the human major histocompatibility complex (MHC), 53 YACs, with an average size of 490 kb, were isolated and characterized from the CEPH YAC library. These YACs were organized in a single large contig covering more than 4000 kb. Furthermore, a complete physical map of the previously uncloned HLA class I region was established from partial and/or total digestions of 15 YACs spanning 2000 kb. This resulted in the establishment of the first YAC contig that spans the entire MHC region and constitutes an essential step in the isolation of all of the genes present in the region.

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Year:  1994        PMID： 7851878     DOI： 10.1006/geno.1994.1538

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  14 in total

1.  Molecular dynamics of MHC genesis unraveled by sequence analysis of the 1,796,938-bp HLA class I region.

Authors:  T Shiina; G Tamiya; A Oka; N Takishima; T Yamagata; E Kikkawa; K Iwata; M Tomizawa; N Okuaki; Y Kuwano; K Watanabe; Y Fukuzumi; S Itakura; C Sugawara; A Ono; M Yamazaki; H Tashiro; A Ando; T Ikemura; E Soeda; M Kimura; S Bahram; H Inoko
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-09       Impact factor: 11.205

2.  A new non-HLA multigene family associated with the PERB11 family within the MHC class I region.

Authors:  L Pichon; A Hampe; T Giffon; G Carn; J Y Legall; V David
Journal:  Immunogenetics       Date:  1996       Impact factor: 2.846

3.  The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein.

Authors:  A Khanna; R D Campbell
Journal:  Biochem J       Date:  1996-10-01       Impact factor: 3.857

4.  Construction of a swine YAC library allowing an efficient recovery of unique and centromeric repeated sequences.

Authors:  C Rogel-Gaillard; N Bourgeaux; J C Save; C Renard; P Coullin; P Pinton; M Yerle; M Vaiman; P Chardon
Journal:  Mamm Genome       Date:  1997-03       Impact factor: 2.957

5.  Haplotype analysis of hemochromatosis: evaluation of different linkage-disequilibrium approaches and evolution of disease chromosomes.

Authors:  R S Ajioka; L B Jorde; J R Gruen; P Yu; D Dimitrova; J Barrow; E Radisky; C Q Edwards; L M Griffen; J P Kushner
Journal:  Am J Hum Genet       Date:  1997-06       Impact factor: 11.025

6.  Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region.

Authors:  C Vernet; M T Ribouchon; G Chimini; P Pontarotti
Journal:  Mamm Genome       Date:  1994-02       Impact factor: 2.957

7.  Linkage disequilibrium and extended haplotypes in the HLA-A to D6S105 region: implications for mapping the hemochromatosis gene (HFE).

Authors:  G Gandon; A M Jouanolle; B Chauvel; V Mauvieux; A le Treut; J Feingold; J Y Le Gall; V David; J Yaouanq
Journal:  Hum Genet       Date:  1996-01       Impact factor: 4.132

8.  Genomic organization of a mouse MHC class II region including the H2-M and Lmp2 loci.

Authors:  A Péléraux; L Karlsson; J Chambers; P A Peterson
Journal:  Immunogenetics       Date:  1996       Impact factor: 2.846

9.  Physical map of the HLA-A/HLA-F subregion and identification of two new coding sequences.

Authors:  L Pichon; T Giffon; B Chauvel; G Carn; P Bouric; A El Kahloun; J Y Legall; V David
Journal:  Immunogenetics       Date:  1996       Impact factor: 2.846

10.  A new highly polymorphic marker in the 5' untranslated region of HLA-F shows strong allelic association with haemochromatosis.

Authors:  R Raha-Chowdhury; D J Bowen; M Worwood
Journal:  Hum Genet       Date:  1996-02       Impact factor: 4.132
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