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Literature DB >> 8575815

Physical map of the HLA-A/HLA-F subregion and identification of two new coding sequences.

L Pichon¹, T Giffon, B Chauvel, G Carn, P Bouric, A El Kahloun, J Y Legall, V David.

Abstract

As part of an effort to characterize the hemochromatosis gene, we selected three non-chimeric yeast artificial chromosomes (YACs) overlapping with the YAC B30 previously described and forming an 800 kilobase contig covering the HLA-A/HLA-F region. The precise physical map of these YACs and of the corresponding genomic region were established. Nine concentrated sites of CpG cutter elements, potentially HTF islands, were mapped. In addition, several probes have been generated as tools for mapping and examining transcripts produced in the region. This allowed for the characterization and localization of two new coding sequences, provisionally named HCG (for hemochromatosis candidate gene) and numbered VIII and IX.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1996 PMID： 8575815 DOI： 10.1007/BF00587297

Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846

52 in total

1. Molecular analysis of the human MHC class I region using yeast artificial chromosome clones.

Authors: G Chimini; J Boretto; D Marguet; F Lanau; G Lauquin; P Pontarotti
Journal: Immunogenetics Date: 1990 Impact factor: 2.846

2. Isolation and characterization of yeast artificial chromosome clones linking the HLA-B and HLA-C loci.

Authors: S K Bronson; J Pei; P Taillon-Miller; M J Chorney; D E Geraghty; D D Chaplin
Journal: Proc Natl Acad Sci U S A Date: 1991-03-01 Impact factor: 11.205

3. Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region.

Authors: C Vernet; M T Ribouchon; G Chimini; P Pontarotti
Journal: Mamm Genome Date: 1994-02 Impact factor: 2.957

4. Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction.

Authors: A Volz; E Weiss; J Trowsdale; A Ziegler
Journal: Hum Genet Date: 1994-01 Impact factor: 4.132

Physical map of the HLA-A/HLA-F subregion and identification of two new coding sequences.

1. Molecular analysis of the human MHC class I region using yeast artificial chromosome clones.

2. Isolation and characterization of yeast artificial chromosome clones linking the HLA-B and HLA-C loci.

3. Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region.

4. Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction.

5. Localization of seven new genes around the HLA-A locus.

6. Localization of the hemochromatosis gene close to D6S105.

7. A second lineage of mammalian major histocompatibility complex class I genes.

8. Predicting internal exons by oligonucleotide composition and discriminant analysis of spliceable open reading frames.

9. Cloning of a new "finger" protein gene (ZNF173) within the class I region of the human MHC.

10. Evolutionary study of multigenic families mapping close to the human MHC class I region.

1. A new non-HLA multigene family associated with the PERB11 family within the MHC class I region.

2. Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region.