Literature DB >> 7851744

Expression and sequence of outer surface protein C among North American isolates of Borrelia burgdorferi.

B Stevenson1, S W Barthold.   

Abstract

The expression of outer surface protein C (OspC) was determined for North American Borrelia burgdorferi isolates HB19, DN127cl9-2, 25015 and both low and high culture passage B31. A monoclonal antibody detected the presence of OspC protein in only two isolates, while polyclonal antiserum identified this protein in all five isolates. The ospC gene was cloned and sequenced for isolates HB19, DN127cl9-2 and 25015, and compared with the published ospC sequences of other Lyme disease spirochetes. Both the nucleotide and amino acid sequences were found to vary as much among isolates from the same geographic area as between isolates of different species.

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Year:  1994        PMID： 7851744     DOI： 10.1111/j.1574-6968.1994.tb07310.x

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  19 in total

1.  Borrelia burgdorferi B31 Erp proteins that are dominant immunoblot antigens of animals infected with isolate B31 are recognized by only a subset of human lyme disease patient sera.

Authors:  J C Miller; N El-Hage; K Babb; B Stevenson
Journal:  J Clin Microbiol       Date:  2000-04       Impact factor: 5.948

2.  Variable tick protein in two genomic groups of the relapsing fever spirochete Borrelia hermsii in western North America.

Authors:  Stephen F Porcella; Sandra J Raffel; Donald E Anderson; Stacey D Gilk; James L Bono; Merry E Schrumpf; Tom G Schwan
Journal:  Infect Immun       Date:  2005-10       Impact factor: 3.441

3.  Stability of erp loci during Borrelia burgdorferi infection: recombination is not required for chronic infection of immunocompetent mice.

Authors:  N El Hage; L D Lieto; B Stevenson
Journal:  Infect Immun       Date:  1999-06       Impact factor: 3.441

4.  Borreliacidal OspC antibodies specific for a highly conserved epitope are immunodominant in human lyme disease and do not occur in mice or hamsters.

Authors:  Steven D Lovrich; Dean A Jobe; Ronald F Schell; Steven M Callister
Journal:  Clin Diagn Lab Immunol       Date:  2005-06

5.  The dominant epitope of Borrelia garinii outer surface protein C recognized by sera from patients with neuroborreliosis has a surface-exposed conserved structural motif.

Authors:  M J Mathiesen; A Holm; M Christiansen; J Blom; K Hansen; S Ostergaard; M Theisen
Journal:  Infect Immun       Date:  1998-09       Impact factor: 3.441

6.  Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi.

Authors:  B Stevenson; T G Schwan; P A Rosa
Journal:  Infect Immun       Date:  1995-11       Impact factor: 3.441

7.  Borrelia burgdorferi complement regulator-acquiring surface protein 2 (CspZ) as a serological marker of human Lyme disease.

Authors:  Peter Kraiczy; Annekatrin Seling; Catherine A Brissette; Evelyn Rossmann; Klaus-Peter Hunfeld; Tomasz Bykowski; Logan H Burns; Matthew J Troese; Anne E Cooley; Jennifer C Miller; Volker Brade; Reinhard Wallich; Sherwood Casjens; Brian Stevenson
Journal:  Clin Vaccine Immunol       Date:  2007-12-26

8.  Directed insertion of a selectable marker into a circular plasmid of Borrelia burgdorferi.

Authors:  P Rosa; D S Samuels; D Hogan; B Stevenson; S Casjens; K Tilly
Journal:  J Bacteriol       Date:  1996-10       Impact factor: 3.490

9.  Differential expression of Borrelia burgdorferi proteins during growth in vitro.

Authors:  R Ramamoorthy; M T Philipp
Journal:  Infect Immun       Date:  1998-11       Impact factor: 3.441

10.  Molecular characterization of Borrelia burgdorferi erp promoter/operator elements.

Authors:  Kelly Babb; Jason D McAlister; Jennifer C Miller; Brian Stevenson
Journal:  J Bacteriol       Date:  2004-05       Impact factor: 3.490
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