Literature DB >> 10338534

Stability of erp loci during Borrelia burgdorferi infection: recombination is not required for chronic infection of immunocompetent mice.

N El Hage1, L D Lieto, B Stevenson.   

Abstract

Borrelia burgdorferi can persistently infect mammals despite their production of antibodies directed against bacterial proteins, including the Erp lipoproteins. We sequenced erp loci of bacteria reisolated from laboratory mice after 1 year of infection and found them to be identical to those of the inoculant bacteria. We conclude that recombination of erp genes is not essential for chronic mammalian infection.

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Year:  1999        PMID： 10338534      PMCID： PMC96635          DOI： 10.1128/IAI.67.6.3146-3150.1999

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  62 in total

1.  Borrelia burgdorferi erp proteins are immunogenic in mammals infected by tick bite, and their synthesis is inducible in cultured bacteria.

Authors:  B Stevenson; J L Bono; T G Schwan; P Rosa
Journal:  Infect Immun       Date:  1998-06       Impact factor: 3.441

2.  Spirochetes isolated from the blood of two patients with Lyme disease.

Authors:  J L Benach; E M Bosler; J P Hanrahan; J L Coleman; G S Habicht; T F Bast; D J Cameron; J L Ziegler; A G Barbour; W Burgdorfer; R Edelman; R A Kaslow
Journal:  N Engl J Med       Date:  1983-03-31       Impact factor: 91.245

3.  The spirochetal etiology of Lyme disease.

Authors:  A C Steere; R L Grodzicki; A N Kornblatt; J E Craft; A G Barbour; W Burgdorfer; G P Schmid; E Johnson; S E Malawista
Journal:  N Engl J Med       Date:  1983-03-31       Impact factor: 91.245

4.  A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi.

Authors:  S Casjens; N Palmer; R van Vugt; W M Huang; B Stevenson; P Rosa; R Lathigra; G Sutton; J Peterson; R J Dodson; D Haft; E Hickey; M Gwinn; O White; C M Fraser
Journal:  Mol Microbiol       Date:  2000-02       Impact factor: 3.501

5.  Bacteriophage in the Ixodes dammini spirochete, etiological agent of Lyme disease.

Authors:  S F Hayes; W Burgdorfer; A G Barbour
Journal:  J Bacteriol       Date:  1983-06       Impact factor: 3.490

6.  Experimental Lyme disease in dogs produces arthritis and persistent infection.

Authors:  M J Appel; S Allan; R H Jacobson; T L Lauderdale; Y F Chang; S J Shin; J W Thomford; R J Todhunter; B A Summers
Journal:  J Infect Dis       Date:  1993-03       Impact factor: 5.226

7.  Long-term study of cell-mediated responses to Borrelia burgdorferi in the laboratory mouse.

Authors:  M S de Souza; A L Smith; D S Beck; G A Terwilliger; E Fikrig; S W Barthold
Journal:  Infect Immun       Date:  1993-05       Impact factor: 3.441

8.  Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversion.

Authors:  J R Zhang; S J Norris
Journal:  Infect Immun       Date:  1998-08       Impact factor: 3.441

9.  Kinetics and in vivo induction of genetic variation of vlsE in Borrelia burgdorferi.

Authors:  J R Zhang; S J Norris
Journal:  Infect Immun       Date:  1998-08       Impact factor: 3.441

10.  Antigenic variation of Borrelia hermsii.

Authors:  H G Stoenner; T Dodd; C Larsen
Journal:  J Exp Med       Date:  1982-11-01       Impact factor: 14.307
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  22 in total

1.  Molecular and evolutionary characterization of the cp32/18 family of supercoiled plasmids in Borrelia burgdorferi 297.

Authors:  M J Caimano; X Yang; T G Popova; M L Clawson; D R Akins; M V Norgard; J D Radolf
Journal:  Infect Immun       Date:  2000-03       Impact factor: 3.441

2.  Mutation and recombination in the upstream homology box-flanked ospE-related genes of the Lyme disease spirochetes result in the development of new antigenic variants during infection.

Authors:  S Y Sung; J V McDowell; J A Carlyon; R T Marconi
Journal:  Infect Immun       Date:  2000-03       Impact factor: 3.441

Review 3.  Spirochaetal lipoproteins and pathogenesis.

Authors:  D A Haake
Journal:  Microbiology       Date:  2000-07       Impact factor: 2.777

4.  A second allele of eppA in Borrelia burgdorferi strain B31 is located on the previously undetected circular plasmid cp9-2.

Authors:  J C Miller; J L Bono; K Babb; N El-Hage; S Casjens; B Stevenson
Journal:  J Bacteriol       Date:  2000-11       Impact factor: 3.490

5.  Borrelia burgdorferi B31 Erp proteins that are dominant immunoblot antigens of animals infected with isolate B31 are recognized by only a subset of human lyme disease patient sera.

Authors:  J C Miller; N El-Hage; K Babb; B Stevenson
Journal:  J Clin Microbiol       Date:  2000-04       Impact factor: 5.948

6.  The relapsing fever spirochete Borrelia hermsii contains multiple, antigen-encoding circular plasmids that are homologous to the cp32 plasmids of Lyme disease spirochetes.

Authors:  B Stevenson; S F Porcella; K L Oie; C A Fitzpatrick; S J Raffel; L Lubke; M E Schrumpf; T G Schwan
Journal:  Infect Immun       Date:  2000-07       Impact factor: 3.441

7.  Temporal expression analysis of the Borrelia burgdorferi paralogous gene family 54 genes BBA64, BBA65, and BBA66 during persistent infection in mice.

Authors:  Robert D Gilmore; Rebekah R Howison; Virginia L Schmit; Andrew J Nowalk; Dawn R Clifton; Christi Nolder; Jessica L Hughes; James A Carroll
Journal:  Infect Immun       Date:  2007-03-19       Impact factor: 3.441

8.  Differential binding of host complement inhibitor factor H by Borrelia burgdorferi Erp surface proteins: a possible mechanism underlying the expansive host range of Lyme disease spirochetes.

Authors:  Brian Stevenson; Nazira El-Hage; Melissa A Hines; Jennifer C Miller; Kelly Babb
Journal:  Infect Immun       Date:  2002-02       Impact factor: 3.441

9.  Simultaneous coexpression of Borrelia burgdorferi Erp proteins occurs through a specific, erp locus-directed regulatory mechanism.

Authors:  Nazira El-Hage; Brian Stevenson
Journal:  J Bacteriol       Date:  2002-08       Impact factor: 3.490

10.  Borrelia burgdorferi complement regulator-acquiring surface protein 2 (CspZ) as a serological marker of human Lyme disease.

Authors:  Peter Kraiczy; Annekatrin Seling; Catherine A Brissette; Evelyn Rossmann; Klaus-Peter Hunfeld; Tomasz Bykowski; Logan H Burns; Matthew J Troese; Anne E Cooley; Jennifer C Miller; Volker Brade; Reinhard Wallich; Sherwood Casjens; Brian Stevenson
Journal:  Clin Vaccine Immunol       Date:  2007-12-26
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