Literature DB >> 7851535

Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L.

A Takeda1, T Yamamoto, Y Nakamura, T Takahashi, T Hibino.   

Abstract

A squamous cell carcinoma antigen (SSCA), which is a member of the serpin family of proteinase inhibitors, was purified from sera of cancer patients. It did not inhibit serine proteinases. However, it non-competitively inhibited human cathepsin L with a Ki of 0.064 nM, but not cathepsins B and H among cysteine proteinases. These results indicated that SCCA is a non-functional serpin that inhibits cathepsin L in cancer cells.

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Year:  1995        PMID： 7851535     DOI： 10.1016/0014-5793(94)01456-b

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

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Journal:  Semin Cell Dev Biol       Date:  2016-09-13       Impact factor: 7.727

2.  Inactivation of papain by antithrombin due to autolytic digestion: a model of serpin inactivation of cysteine proteinases.

Authors:  I Björk; K Nordling; E Raub-Segall; U Hellman; S T Olson
Journal:  Biochem J       Date:  1998-11-01       Impact factor: 3.857

3.  Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury.

Authors:  Erica Ullman; Ji-An Pan; Wei-Xing Zong
Journal:  Mol Cell Biol       Date:  2011-05-16       Impact factor: 4.272

4.  SERPINB3 (serpin peptidase inhibitor, clade B (ovalbumin), member 3).

Authors:  Cristian Turato; Patrizia Pontisso
Journal:  Atlas Genet Cytogenet Oncol Haematol       Date:  2015

5.  Heparin enhances serpin inhibition of the cysteine protease cathepsin L.

Authors:  Wayne J Higgins; Denise M Fox; Piotr S Kowalski; Jens E Nielsen; D Margaret Worrall
Journal:  J Biol Chem       Date:  2009-12-03       Impact factor: 5.157

6.  The reactive site loop of the serpin SCCA1 is essential for cysteine proteinase inhibition.

Authors:  C Schick; D Brömme; A J Bartuski; Y Uemura; N M Schechter; G A Silverman
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-10       Impact factor: 11.205

7.  IgM-linked SerpinB3 and SerpinB4 in sera of patients with chronic liver disease.

Authors:  Alessandra Biasiolo; Natascia Tono; Mariagrazia Ruvoletto; Santina Quarta; Cristian Turato; Gianmarco Villano; Luca Beneduce; Giorgio Fassina; Carlo Merkel; Angelo Gatta; Patrizia Pontisso
Journal:  PLoS One       Date:  2012-07-13       Impact factor: 3.240

8.  Inhibition of apoptosis in human tumour cells by the tumour-associated serpin, SCC antigen-1.

Authors:  Y Suminami; S Nagashima; N L Vujanovic; K Hirabayashi; H Kato; T L Whiteside
Journal:  Br J Cancer       Date:  2000-02       Impact factor: 7.640

9.  Squamous cell carcinoma antigen expression in tumor cells is associated with the chemosensitivity and survival of patients with cervical cancer receiving docetaxel-carboplatin-based neoadjuvant chemotherapy.

Authors:  Peng Chen; Liang Jiao; Dan-Bo Wang
Journal:  Oncol Lett       Date:  2017-01-02       Impact factor: 2.967

10.  Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase.

Authors:  Chika Katagiri; Jotaro Nakanishi; Kuniko Kadoya; Toshihiko Hibino
Journal:  J Cell Biol       Date:  2006-03-20       Impact factor: 10.539
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