S D Nathanson1, L Nelson. 1. Department of Surgery, Henry Ford Hospital, Detroit, Michigan 48202.
Abstract
BACKGROUND: Interstitial fluid pressure (IFP) in rodent malignant tumors is reportedly much higher than in surrounding normal tissue. We hypothesized the same may be true in human invasive breast tumors. METHODS: We measured IFP in the operating room in 25 patients undergoing excision breast biopsy under local anesthetic for diagnostic purposes. RESULTS: In patients with invasive ductal carcinomas IFP was 29 +/- 3 (SE) mm Hg, compared with -0.3 +/- 0.1 mm Hg in those with normal breast parenchyma (p < 0.001), 3.6 +/- 0.8 mm Hg in those with benign tumors (p < 0.003), -0.3 +/- 0.2 mm Hg in those with noninvasive carcinomas (p = 0.034), and 0.4 +/- 0.4 mm Hg in those with other benign breast conditions (p = 0.002). There was a direct correlation between IFP and tumor size (R2 = 0.3977; p = 0.021). No correlation was found between IFP and nuclear grade, angiolymphatic invasion, systemic blood pressure, metastasis to lymph nodes, or estrogen and progesterone receptors. CONCLUSIONS: IFP measurements may facilitate radiographic or ultrasound localization of small or nonpalpable malignant tumors in those patients undergoing needle aspiration cytology or stereotactic core needle biopsy.
BACKGROUND: Interstitial fluid pressure (IFP) in rodent malignant tumors is reportedly much higher than in surrounding normal tissue. We hypothesized the same may be true in human invasive breast tumors. METHODS: We measured IFP in the operating room in 25 patients undergoing excision breast biopsy under local anesthetic for diagnostic purposes. RESULTS: In patients with invasive ductal carcinomas IFP was 29 +/- 3 (SE) mm Hg, compared with -0.3 +/- 0.1 mm Hg in those with normal breast parenchyma (p < 0.001), 3.6 +/- 0.8 mm Hg in those with benign tumors (p < 0.003), -0.3 +/- 0.2 mm Hg in those with noninvasive carcinomas (p = 0.034), and 0.4 +/- 0.4 mm Hg in those with other benign breast conditions (p = 0.002). There was a direct correlation between IFP and tumor size (R2 = 0.3977; p = 0.021). No correlation was found between IFP and nuclear grade, angiolymphatic invasion, systemic blood pressure, metastasis to lymph nodes, or estrogen and progesterone receptors. CONCLUSIONS: IFP measurements may facilitate radiographic or ultrasound localization of small or nonpalpable malignant tumors in those patients undergoing needle aspiration cytology or stereotactic core needle biopsy.
Authors: Inge R H M Konings; Frederike K Engels; Stefan Sleijfer; Jaap Verweij; Erik A C Wiemer; Walter J Loos Journal: Cancer Chemother Pharmacol Date: 2008-12-20 Impact factor: 3.333
Authors: Marlys H Witte; Michael T Dellinger; Donald M McDonald; S David Nathanson; Francesco M Boccardo; Corradino C C Campisi; Jonathan P Sleeman; Jeffrey E Gershenwald Journal: J Surg Oncol Date: 2011-05-01 Impact factor: 3.454
Authors: Sharon Wei Ling Lee; R J Seager; Felix Litvak; Fabian Spill; Je Lin Sieow; Penny Hweixian Leong; Dillip Kumar; Alrina Shin Min Tan; Siew Cheng Wong; Giulia Adriani; Muhammad Hamid Zaman; And Roger D Kamm Journal: Integr Biol (Camb) Date: 2020-04-20 Impact factor: 2.192
Authors: Ingrid Moen; Karl J Tronstad; Odd Kolmannskog; Gerd S Salvesen; Rolf K Reed; Linda E B Stuhr Journal: BMC Cancer Date: 2009-12-17 Impact factor: 4.430