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Literature DB >> 7849395

Ifg, Gli, Mdm1, Mdm2, and Mdm3: candidate genes for the mouse pg locus.

H R Ashar¹, K F Benson, N A Jenkins, D J Gilbert, N G Copeland, K K Chada.

Abstract

Various genes that mapped to the distal end of Chromosome (Chr) 10 were considered as possible candidates for the mouse pygmy (pg) locus. Probes derived from Ifg, Gli, Mdm1, Mdm2, and Mdm3 (Mdm2 and Mdm3 are genes that are coamplified with Mdm1 on the same double minute chromosomes in 3T3DM cells) were used for Southern analysis of DNA from wild-type mice and various pg mutants. In addition, the chromosomal locations of Ifg, Gli, Mdm1, Mdm2, and Mdm3 were determined by interspecific backcross analysis with progeny derived from matings of [(C57BL/6J x Mus spretus)F1 x C57BL/6J] mice. The mapping data indicate that the Mdm loci are linked to each other and to Ifg, pg, and Gli in the distal region of mouse Chr 10. Both the mapping data and the Southern analysis confirm that Mdm1, Mdm2, Mdm3, Ifg, and Gli are distinct from pg.

Entities: Gene Species

Mesh：

Year: 1994 PMID： 7849395 DOI： 10.1007/bf00411454

Source DB: PubMed Journal: Mamm Genome ISSN： 0938-8990 Impact factor: 2.957

17 in total

Review 1. Development and applications of a molecular genetic linkage map of the mouse genome.

Authors: N G Copeland; N A Jenkins
Journal: Trends Genet Date: 1991-04 Impact factor: 11.639

2. A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross.

Authors: M J Justice; L D Siracusa; D J Gilbert; N Heisterkamp; J Groffen; K Chada; C M Silan; N G Copeland; N A Jenkins
Journal: Genetics Date: 1990-08 Impact factor: 4.562

3. Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line.

Authors: L Cahilly-Snyder; T Yang-Feng; U Francke; D L George
Journal: Somat Cell Mol Genet Date: 1987-05

4. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.

Authors: A P Feinberg; B Vogelstein
Journal: Anal Biochem Date: 1984-02 Impact factor: 3.365

5. Close linkage of Mdm-1, a gene amplified and overexpressed in a transformed 3T3 cell line, with gamma interferon (Ifg) on chromosome 10 of the mouse.

Authors: B A Taylor; L Rowe; D Grieco
Journal: Mamm Genome Date: 1992 Impact factor: 2.957

1. Molecular characterization of the mouse In(10)17Rk inversion and identification of a novel muscle-specific gene at the proximal breakpoint.

Authors: Kathleen F Benson; Kiran Chada
Journal: Genetics Date: 2002-01 Impact factor: 4.562

2. Genomic structure and expression of the murine Hmgi-c gene.

Authors: X Zhou; K F Benson; K Przybysz; J Liu; Y Hou; L Cherath; K Chada
Journal: Nucleic Acids Res Date: 1996-10-15 Impact factor: 16.971

3. Identification and characterization of a novel conserved DNA repeat.

Authors: L Cherath; K F Benson; K Chada
Journal: Mamm Genome Date: 1995-09 Impact factor: 2.957

3 in total

Ifg, Gli, Mdm1, Mdm2, and Mdm3: candidate genes for the mouse pg locus.

Review 1. Development and applications of a molecular genetic linkage map of the mouse genome.

2. A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross.

3. Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line.

4. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.

5. Close linkage of Mdm-1, a gene amplified and overexpressed in a transformed 3T3 cell line, with gamma interferon (Ifg) on chromosome 10 of the mouse.

6. Amplification of a gene encoding a p53-associated protein in human sarcomas.

Review 7. Insertional mutation of 'classical' and novel genes in transgenic mice.

8. The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.

9. Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11).

10. Mini-mouse: disruption of the pygmy locus in a transgenic insertional mutant.

1. Molecular characterization of the mouse In(10)17Rk inversion and identification of a novel muscle-specific gene at the proximal breakpoint.

2. Genomic structure and expression of the murine Hmgi-c gene.

3. Identification and characterization of a novel conserved DNA repeat.