Literature DB >> 1475845

Insertional mutation of 'classical' and novel genes in transgenic mice.

M H Meisler1.   

Abstract

Approximately 5% of established transgenic lines carry insertional mutations. The mutated genes may be directly isolated using the transgene DNA as a molecular probe. These mutants provide useful models of human inherited disorders and developmental abnormalities.

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Mesh：

Year:  1992        PMID： 1475845     DOI： 10.1016/0168-9525(92)90278-c

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  32 in total

1.  A transgenic insertional inner ear mutation on mouse chromosome 1.

Authors:  R A Friedman; Y Adir; E B Crenshaw; A F Ryan; M G Rosenfeld
Journal:  Laryngoscope       Date:  2000-04       Impact factor: 3.325

2.  A large-scale insertional mutagenesis screen in zebrafish.

Authors:  A Amsterdam; S Burgess; G Golling; W Chen; Z Sun; K Townsend; S Farrington; M Haldi; N Hopkins
Journal:  Genes Dev       Date:  1999-10-15       Impact factor: 11.361

3.  Disruption of the murine Ap2β1 gene causes nonsyndromic cleft palate.

Authors:  Wei Li; Rosa Puertollano; Juan S Bonifacino; Paul A Overbeek; Eric T Everett
Journal:  Cleft Palate Craniofac J       Date:  2010-03-02

4.  Transgene insertion in proximity to the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcation.

Authors:  Harumi Y Mukai; Hozumi Motohashi; Osamu Ohneda; Norio Suzuki; Masumi Nagano; Masayuki Yamamoto
Journal:  Mol Cell Biol       Date:  2006-08-28       Impact factor: 4.272

Review 5.  The role of the laboratory mouse in the human genome project.

Authors:  M H Meisler
Journal:  Am J Hum Genet       Date:  1996-10       Impact factor: 11.025

6.  Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness.

Authors:  Giuseppina Somma; Heather M Alger; Ryan M McGuire; Jim D Kretlow; Fernanda R Ruiz; Svetlana A Yatsenko; Pawel Stankiewicz; Wilbur Harrison; Etai Funk; Antonio Bergamaschi; John S Oghalai; Antonios G Mikos; Paul A Overbeek; Fred A Pereira
Journal:  J Assoc Res Otolaryngol       Date:  2012-03-02

7.  Ubiquitous expression of mRFP-1 in vivo by site-directed transgenesis.

Authors:  Ekaterina Yurchenko; Hanna Friedman; Valerie Hay; Alan Peterson; Ciriaco A Piccirillo
Journal:  Transgenic Res       Date:  2006-11-01       Impact factor: 2.788

8.  Rapid fluorescence in situ hybridization on interphasic nuclei to discriminate between homozygous and heterozygous transgenic mice.

Authors:  D Paris; K Toyama; A Mégarbané; P M Casanova; P M Sinet; J London
Journal:  Transgenic Res       Date:  1996-11       Impact factor: 2.788

9.  Mouse genetic corneal disease resulting from transgenic insertional mutagenesis.

Authors:  J S Ramalho; K Gregory-Evans; C Huxley; M C Seabra
Journal:  Br J Ophthalmol       Date:  2004-03       Impact factor: 4.638

10.  Intraclonal protein expression heterogeneity in recombinant CHO cells.

Authors:  Warren Pilbrough; Trent P Munro; Peter Gray
Journal:  PLoS One       Date:  2009-12-23       Impact factor: 3.240
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