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Literature DB >> 7848641

Histamine and leukotriene C4 effects on in vitro ciliary beat frequency of human upper respiratory cilia.

P J Schuil¹, J M van Gelder, M ten Berge, K Graamans, E H Huizing.

Abstract

Decreased mucociliary transport can occur in patients with type I (IgE-mediated) allergic rhinitis or allergic asthma. This study investigated if the allergic mediators histamine and leukotriene C4 (LTC4) could interfere with ciliary beat frequency (CBF) of in vitro human upper respiratory cilia and eventually result in decreased mucociliary transport. Ciliated epithelium of human adenoid tissue was used in the experiments and CBF was determined using a computer-assisted photoelectric method. Histamine in concentrations of 10(-6) - 10(-3) M (n = 12) and LTC4 as 10(-9) - 10(-6) M solutions (n = 10) showed no statistically significant dose-dependent effect on CBF in vitro.

Entities: Chemical Disease Species

Mesh：

Substances：
Leukotriene C4
Histamine

Year: 1994 PMID： 7848641 DOI： 10.1007/bf00171538

Source DB: PubMed Journal: Eur Arch Otorhinolaryngol ISSN： 0937-4477 Impact factor: 2.503

24 in total

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Authors: J Dolata; S Lindberg; U Mercke
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7 in total

1. Effects of histamine on ciliary beat frequency of ciliated cells from guinea pigs nasal mucosa.

Authors: Fengwei An; Lijun Xing; Zhiqiang Zhang; Lei Chen
Journal: Eur Arch Otorhinolaryngol Date: 2014-11-04 Impact factor: 2.503

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Authors: S L Spector
Journal: Drugs Date: 1997-09 Impact factor: 9.546

3. Calcitonin gene-related peptide in vitro stimulation of ciliary beat in human upper respiratory cilia.

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Journal: Eur Arch Otorhinolaryngol Date: 1995 Impact factor: 2.503

Review 4. Cilia dysfunction in lung disease.

Authors: Ann E Tilley; Matthew S Walters; Renat Shaykhiev; Ronald G Crystal
Journal: Annu Rev Physiol Date: 2014-10-29 Impact factor: 19.318