Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Calcitonin gene-related peptide in vitro stimulation of ciliary beat in human upper respiratory cilia.

Literature DB >> 8719586

Calcitonin gene-related peptide in vitro stimulation of ciliary beat in human upper respiratory cilia.

P J Schuil¹, J G Rosmalen, K Graamans, E H Huizing.

Abstract

Calcitonin gene-related peptide (CGRP) is one of the neuropeptides that is released in the human nasal mucosa after trigeminal nerve stimulation. We investigated the in vitro effect of CGRP on the ciliary beat frequency (CBF) of human upper respiratory cilia. Ciliated epithelium of freshly removed adenoidal tissues was used in all experiments. CBF was measured using a computerized photo-electric method. The results showed that CGRP exerted a significant dose-dependent stimulation on CBF in concentrations of 10(-9)-10(-6) M (n = 10), with a maximum of 23%. Our findings indicate that CGRP in vivo may help to protect the airway epithelium by directly stimulating ciliary beat.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1995 PMID： 8719586 DOI： 10.1007/BF02114751

Source DB: PubMed Journal: Eur Arch Otorhinolaryngol ISSN： 0937-4477 Impact factor: 2.503

18 in total

1. Effects of substance P and calcitonin gene related peptide (CGRP) on guinea pig nasal mucosal secretion in vivo.

Authors: A Z Gawin; J N Baraniuk; M A Kaliner
Journal: Acta Otolaryngol Date: 1993-07 Impact factor: 1.494

2. [Pharmacologic studies of cultivated human ciliated cells of the upper respiratory tract].

Authors: G Wolf; A Saria; B Koidl
Journal: Laryngol Rhinol Otol (Stuttg) Date: 1988-10

3. Vasoactive intestinal peptide in human nasal mucosa.

Authors: J N Baraniuk; J D Lundgren; M Okayama; J Mullol; M Merida; J H Shelhamer; M A Kaliner
Journal: J Clin Invest Date: 1990-09 Impact factor: 14.808

4. Effects of calcitonin gene-related peptide on airway epithelial functions in dogs.

Authors: J Tamaoki; T Kanemura; K Kobayashi; N Sakai; T Takizawa
Journal: Peptides Date: 1989 Sep-Oct Impact factor: 3.750

5. Substance-P-containing nerve fibers in the nasal mucosa.

Authors: R Uddman; L Malm; F Sundler
Journal: Arch Otorhinolaryngol Date: 1983

6. Correlation between the sensitivity of the ciliary beat frequency of human adenoid tissue and chicken embryo tracheas for some drugs.

Authors: H J van de Donk; J Zuidema; F W Merkus
Journal: Rhinology Date: 1982-06 Impact factor: 3.681

7. Distinctive patterns of release of neuroendocrine peptides after nasal challenge of allergic subjects with ryegrass antigen.

Authors: K B Walker; M H Serwonska; F H Valone; W S Harkonen; O L Frick; K H Scriven; W D Ratnoff; J G Browning; D G Payan; E J Goetzl
Journal: J Clin Immunol Date: 1988-03 Impact factor: 8.317

Calcitonin gene-related peptide in vitro stimulation of ciliary beat in human upper respiratory cilia.

1. Effects of substance P and calcitonin gene related peptide (CGRP) on guinea pig nasal mucosal secretion in vivo.

2. [Pharmacologic studies of cultivated human ciliated cells of the upper respiratory tract].

3. Vasoactive intestinal peptide in human nasal mucosa.

4. Effects of calcitonin gene-related peptide on airway epithelial functions in dogs.

5. Substance-P-containing nerve fibers in the nasal mucosa.

6. Correlation between the sensitivity of the ciliary beat frequency of human adenoid tissue and chicken embryo tracheas for some drugs.

7. Distinctive patterns of release of neuroendocrine peptides after nasal challenge of allergic subjects with ryegrass antigen.

8. Neuropeptide Y (NPY) in human nasal mucosa.

9. Improvement of symptoms of non-allergic chronic rhinitis by local treatment with capsaicin.

10. Effects of neurokinin A and calcitonin gene-related peptide on mucociliary activity in rabbit maxillary sinus.

1. Ciliogenesis in submersion and suspension cultures of human nasal epithelial cells.