BACKGROUND: This article focuses on the underlying structure and temporal course of the symptoms of schizophrenia. METHODS: Ratings of symptoms in 90 schizophrenic patients were made each month for 10 years following the first hospitalization. The analytic methods consisted of cross-tabulation, dichotomous factor analysis, and bivariate dichotomous time series. RESULTS: The factor analyses revealed positive and negative factors with a slight tendency to merge over time. The prevalence of positive and negative symptoms declined in the year following first hospitalization and was stable thereafter. Positive and negative symptoms in 1 month were highly predictive of the same type of symptoms in the next month. Neither type of symptom was strongly associated with the other type in the following month when both types were included in the model. The predictability of the process increased with time. CONCLUSIONS: With a few minor caveats, the results suggest that the positive and negative symptom clusters are independent, both cross-sectionally and longitudinally.
BACKGROUND: This article focuses on the underlying structure and temporal course of the symptoms of schizophrenia. METHODS: Ratings of symptoms in 90 schizophrenicpatients were made each month for 10 years following the first hospitalization. The analytic methods consisted of cross-tabulation, dichotomous factor analysis, and bivariate dichotomous time series. RESULTS: The factor analyses revealed positive and negative factors with a slight tendency to merge over time. The prevalence of positive and negative symptoms declined in the year following first hospitalization and was stable thereafter. Positive and negative symptoms in 1 month were highly predictive of the same type of symptoms in the next month. Neither type of symptom was strongly associated with the other type in the following month when both types were included in the model. The predictability of the process increased with time. CONCLUSIONS: With a few minor caveats, the results suggest that the positive and negative symptom clusters are independent, both cross-sectionally and longitudinally.
Authors: Jim van Os; Philippe Delespaul; Johanna Wigman; Inez Myin-Germeys; Marieke Wichers Journal: World Psychiatry Date: 2013-06 Impact factor: 49.548
Authors: Rachel N Pläschke; Edna C Cieslik; Veronika I Müller; Felix Hoffstaedter; Anna Plachti; Deepthi P Varikuti; Mareike Goosses; Anne Latz; Svenja Caspers; Christiane Jockwitz; Susanne Moebus; Oliver Gruber; Claudia R Eickhoff; Kathrin Reetz; Julia Heller; Martin Südmeyer; Christian Mathys; Julian Caspers; Christian Grefkes; Tobias Kalenscher; Robert Langner; Simon B Eickhoff Journal: Hum Brain Mapp Date: 2017-09-06 Impact factor: 5.038