Literature DB >> 7845611

Cu/Zn superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosis.

N Shibata1, A Hirano, M Kobayashi, S Sasaki, T Kato, S Matsumoto, Z Shiozawa, T Komori, A Ikemoto, T Umahara.   

Abstract

Cu/Zn superoxide dismutase (SOD)-like immunoreactivity (LI) was found within Lewy body-like inclusions (LBIs) in the spinal cords of patients with sporadic amyotrophic lateral sclerosis (ALS) by using an antibody to human Cu/ZnSOD. LBIs were detected in the anterior horn cells in 10 of 20 patients with sporadic ALS. In each of these patients, 7 to 60% of LBIs showed Cu/ZnSOD-LI. No Cu/ZnSOD-LI was detected in intact neurons and glia in the 20 ALS patients, as well as in these cells in 10 normal control individuals. The skein-like inclusions and Bunina bodies, which were found in all of the 20 ALS cases, showed no Cu/ZnSOD-LI. Thus, Cu/ZnSOD appears to play roles in the production and/or degradation process of LBIs.

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Year:  1994        PMID： 7845611     DOI： 10.1016/0304-3940(94)90956-3

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  49 in total

1.  The rate and equilibrium constants for a multistep reaction sequence for the aggregation of superoxide dismutase in amyotrophic lateral sclerosis.

Authors:  Sagar D Khare; Michael Caplow; Nikolay V Dokholyan
Journal:  Proc Natl Acad Sci U S A       Date:  2004-10-08       Impact factor: 11.205

2.  Nonamyloid aggregates arising from mature copper/zinc superoxide dismutases resemble those observed in amyotrophic lateral sclerosis.

Authors:  Young-Mi Hwang; Peter B Stathopulos; Kristin Dimmick; Hong Yang; Hamid R Badiei; Ming Sze Tong; Jessica A O Rumfeldt; Pu Chen; Vassili Karanassios; Elizabeth M Meiering
Journal:  J Biol Chem       Date:  2010-10-25       Impact factor: 5.157

3.  Structural basis of Cu, Zn-superoxide dismutase amyloid fibril formation involves interaction of multiple peptide core regions.

Authors:  Masataka Ida; Mizuho Ando; Masayuki Adachi; Asumi Tanaka; Kodai Machida; Kunihiro Hongo; Tomohiro Mizobata; Miho Yoshida Yamakawa; Yasuhiro Watanabe; Kenji Nakashima; Yasushi Kawata
Journal:  J Biochem       Date:  2015-08-29       Impact factor: 3.387

4.  Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis.

Authors:  Jared R Auclair; Kristin J Boggio; Gregory A Petsko; Dagmar Ringe; Jeffrey N Agar
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-22       Impact factor: 11.205

5.  A structural modeling approach for the understanding of initiation and elongation of ALS-linked superoxide dismutase fibrils.

Authors:  Mattia Falconi; Federico Iacovelli; Alessandro Desideri
Journal:  J Mol Model       Date:  2013-06-19       Impact factor: 1.810

6.  Interaction of amyotrophic lateral sclerosis (ALS)-related mutant copper-zinc superoxide dismutase with the dynein-dynactin complex contributes to inclusion formation.

Authors:  Anna-Lena Ström; Ping Shi; Fujian Zhang; Jozsef Gal; Renee Kilty; Lawrence J Hayward; Haining Zhu
Journal:  J Biol Chem       Date:  2008-05-30       Impact factor: 5.157

7.  SOD1 mutations targeting surface hydrogen bonds promote amyotrophic lateral sclerosis without reducing apo-state stability.

Authors:  Roberth Byström; Peter M Andersen; Gerhard Gröbner; Mikael Oliveberg
Journal:  J Biol Chem       Date:  2010-02-26       Impact factor: 5.157

Review 8.  The perplexing role of copper-zinc superoxide dismutase in amyotrophic lateral sclerosis (Lou Gehrig's disease).

Authors:  Soshanna Zittin Potter; Joan Selverstone Valentine
Journal:  J Biol Inorg Chem       Date:  2003-03-19       Impact factor: 3.358

9.  Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis.

Authors:  Ruth Chia; M Howard Tattum; Samantha Jones; John Collinge; Elizabeth M C Fisher; Graham S Jackson
Journal:  PLoS One       Date:  2010-05-13       Impact factor: 3.240

10.  Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients.

Authors:  Karin Forsberg; P Andreas Jonsson; Peter M Andersen; Daniel Bergemalm; Karin S Graffmo; Magnus Hultdin; Johan Jacobsson; Roland Rosquist; Stefan L Marklund; Thomas Brännström
Journal:  PLoS One       Date:  2010-07-14       Impact factor: 3.240
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