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Literature DB >> 7844154

A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium.

J E Segall¹, A Kuspa, G Shaulsky, M Ecke, M Maeda, C Gaskins, R A Firtel, W F Loomis.

Abstract

Analysis of a developmental mutant in Dictyostelium discoideum which is unable to initiate morphogenesis has shown that a protein kinase of the MAP kinase/ERK family affects relay of the cAMP chemotactic signal and cell differentiation. Strains in which the locus encoding ERK2 is disrupted respond to a pulse of cAMP by synthesizing cGMP normally but show little synthesis of cAMP. Since mutant cells lacking ERK2 contain normal levels of both the cytosolic regulator of adenylyl cyclase (CRAC) and manganese-activatable adenylyl cyclase, it appears that this kinase is important for receptor-mediated activation of adenylyl cyclase.

Entities: Chemical Gene Species

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Year: 1995 PMID： 7844154 PMCID： PMC2120359 DOI： 10.1083/jcb.128.3.405

Source DB: PubMed Journal: J Cell Biol ISSN： 0021-9525 Impact factor: 10.539

64 in total

1. Identification of CRAC, a cytosolic regulator required for guanine nucleotide stimulation of adenylyl cyclase in Dictyostelium.

Authors: P J Lilly; P N Devreotes
Journal: J Biol Chem Date: 1994-05-13 Impact factor: 5.157

Review 2. Finite element methods for developmental biology.

Authors: G W Brodland
Journal: Int Rev Cytol Date: 1994

3. Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

Authors: P Crespo; N Xu; W F Simonds; J S Gutkind
Journal: Nature Date: 1994-06-02 Impact factor: 49.962

4. A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways.

Authors: D Brunner; N Oellers; J Szabad; W H Biggs; S L Zipursky; E Hafen
Journal: Cell Date: 1994-03-11 Impact factor: 41.582

Review 5. Sequential protein kinase reactions controlling cell growth and differentiation.

Authors: G L Johnson; R R Vaillancourt
Journal: Curr Opin Cell Biol Date: 1994-04 Impact factor: 8.382

6. FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase.

Authors: G S Worthen; N Avdi; A M Buhl; N Suzuki; G L Johnson
Journal: J Clin Invest Date: 1994-08 Impact factor: 14.808

7. LagC is required for cell-cell interactions that are essential for cell-type differentiation in Dictyostelium.

Authors: J L Dynes; A M Clark; G Shaulsky; A Kuspa; W F Loomis; R A Firtel
Journal: Genes Dev Date: 1994-04-15 Impact factor: 11.361

8. Cloning and characterization of the G-box binding factor, an essential component of the developmental switch between early and late development in Dictyostelium.

Authors: G R Schnitzler; W H Fischer; R A Firtel
Journal: Genes Dev Date: 1994-02-15 Impact factor: 11.361

9. cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.

Authors: M Faure; T A Voyno-Yasenetskaya; H R Bourne
Journal: J Biol Chem Date: 1994-03-18 Impact factor: 5.157

10. CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium.

Authors: R Insall; A Kuspa; P J Lilly; G Shaulsky; L R Levin; W F Loomis; P Devreotes
Journal: J Cell Biol Date: 1994-09 Impact factor: 10.539

66 in total

1. The internal phosphodiesterase RegA is essential for the suppression of lateral pseudopods during Dictyostelium chemotaxis.

Authors: D J Wessels; H Zhang; J Reynolds; K Daniels; P Heid; S Lu; A Kuspa; G Shaulsky; W F Loomis; D R Soll
Journal: Mol Biol Cell Date: 2000-08 Impact factor: 4.138

A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium.

1. Identification of CRAC, a cytosolic regulator required for guanine nucleotide stimulation of adenylyl cyclase in Dictyostelium.

Review 2. Finite element methods for developmental biology.

3. Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

4. A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways.

Review 5. Sequential protein kinase reactions controlling cell growth and differentiation.

6. FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase.

7. LagC is required for cell-cell interactions that are essential for cell-type differentiation in Dictyostelium.

8. Cloning and characterization of the G-box binding factor, an essential component of the developmental switch between early and late development in Dictyostelium.

9. cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.

10. CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium.

1. The internal phosphodiesterase RegA is essential for the suppression of lateral pseudopods during Dictyostelium chemotaxis.

2. Regulated protein degradation controls PKA function and cell-type differentiation in Dictyostelium.

3. Multiple signalling pathways connect chemoattractant receptors and calcium channels in Dictyostelium.

Review 4. cAMP signaling in Dictyostelium. Complexity of cAMP synthesis, degradation and detection.

5. The cyclase-associated protein CAP as regulator of cell polarity and cAMP signaling in Dictyostelium.

Review 6. Genetic control of morphogenesis in Dictyostelium.

7. Nonadaptive regulation of ERK2 in Dictyostelium: implications for mechanisms of cAMP relay.

Review 8. Role of PKA in the timing of developmental events in Dictyostelium cells.

9. G{alpha}5 subunit-mediated signalling requires a D-motif and the MAPK ERK1 in Dictyostelium.

10. Dictyostelium Erk2 is an atypical MAPK required for chemotaxis.