Literature DB >> 7841132

The membrane hypothesis of schizophrenia.

D F Horrobin1, A I Glen, K Vaddadi.   

Abstract

The phospholipid structure of neuronal membranes is essential for normal functioning of the nervous system. Evidence is accumulating that phospholipid metabolism in both brain and red blood cells may be disturbed in schizophrenia. In particular, in patients with negative symptoms, levels of arachidonic acid and docosahexanoic acid in red blood cell membrane phospholipids are severely abnormal. The membrane hypothesis of schizophrenia may represent a new and fruitful paradigm for future research.

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Year:  1994        PMID： 7841132     DOI： 10.1016/0920-9964(94)90043-4

Source DB:  PubMed          Journal:  Schizophr Res        ISSN： 0920-9964            Impact factor:   4.939


  47 in total

1.  Candidate gene polymorphisms among North Indians and their association with schizophrenia in a case-control study.

Authors:  Prachi Semwal; Suman Prasad; Panchami G Varma; A M Bhagwat; S N Deshpande; B K Thelma
Journal:  J Genet       Date:  2002-08       Impact factor: 1.166

2.  Epigenomic profiling reveals DNA-methylation changes associated with major psychosis.

Authors:  Jonathan Mill; Thomas Tang; Zachary Kaminsky; Tarang Khare; Simin Yazdanpanah; Luigi Bouchard; Peixin Jia; Abbas Assadzadeh; James Flanagan; Axel Schumacher; Sun-Chong Wang; Arturas Petronis
Journal:  Am J Hum Genet       Date:  2008-03       Impact factor: 11.025

3.  Association studies of cytosolic phospholipase A2 polymorphisms and schizophrenia among two independent family-based samples.

Authors:  K V Chowdari; B Brandstaetter; P Semwal; T Bhatia; S Deshpande; R Reddy; J Wood; C R Weinberg; B K Thelma; V L Nimgaonkar
Journal:  Psychiatr Genet       Date:  2001-12       Impact factor: 2.458

Review 4.  Schizophrenia, "Just the Facts" 6. Moving ahead with the schizophrenia concept: from the elephant to the mouse.

Authors:  Matcheri S Keshavan; Henry A Nasrallah; Rajiv Tandon
Journal:  Schizophr Res       Date:  2011-02-12       Impact factor: 4.939

5.  Profiling of lipidomics before and after antipsychotic treatment in first-episode psychosis.

Authors:  Liisa Leppik; Madis Parksepp; Sven Janno; Kati Koido; Liina Haring; Eero Vasar; Mihkel Zilmer
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2019-01-02       Impact factor: 5.270

6.  Levels of Red Blood Cell Fatty Acids in Patients With Psychosis, Their Unaffected Siblings, and Healthy Controls.

Authors:  Suzanne Medema; Roel J T Mocking; Maarten W J Koeter; Frédéric M Vaz; Carin Meijer; Lieuwe de Haan; Nico J M van Beveren; René Kahn; Lieuwe de Haan; Jim van Os; Durk Wiersma; Richard Bruggeman; Wiepke Cahn; Carin Meijer; Inez Myin-Germeys
Journal:  Schizophr Bull       Date:  2015-09-18       Impact factor: 9.306

Review 7.  Pathways of polyunsaturated fatty acid utilization: implications for brain function in neuropsychiatric health and disease.

Authors:  Joanne J Liu; Pnina Green; J John Mann; Stanley I Rapoport; M Elizabeth Sublette
Journal:  Brain Res       Date:  2014-12-08       Impact factor: 3.252

8.  Altered fatty acid concentrations in prefrontal cortex of schizophrenic patients.

Authors:  Ameer Y Taha; Yewon Cheon; Kaizong Ma; Stanley I Rapoport; Jagadeesh S Rao
Journal:  J Psychiatr Res       Date:  2013-02-18       Impact factor: 4.791

Review 9.  Clinical potential of omega-3 fatty acids in the treatment of schizophrenia.

Authors:  Robin Emsley; Piet Oosthuizen; Susan J van Rensburg
Journal:  CNS Drugs       Date:  2003       Impact factor: 5.749

10.  Magnetic resonance imaging and spectroscopy in a mouse model of schizophrenia.

Authors:  German Torres; Brian H Hallas; Kenneth W Gross; Joseph A Spernyak; Judith M Horowitz
Journal:  Brain Res Bull       Date:  2007-10-17       Impact factor: 4.077
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