Literature DB >> 7840595

Loss of function mutation in the yeast multiple drug resistance gene PDR5 causes a reduction in chloramphenicol efflux.

P J Leonard1, P K Rathod, J Golin.   

Abstract

The yeast (Saccharomyces cerevisiae) PDR5 gene product encodes a 160-kDa protein related to the large ABC family of transporters, including the human MDR1 multidrug resistance p-glycoprotein. Loss of function mutations in PDR5 result in chloramphenicol hypersensitivity. A pdr5::Tn5 loss of function mutant exhibits a markedly impaired efflux of chloramphenicol compared with that of an isogenic PDR5 (wild-type) control.

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Year:  1994        PMID： 7840595      PMCID： PMC284771          DOI： 10.1128/AAC.38.10.2492

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein.

Authors:  D R Gill; S C Hyde; C F Higgins; M A Valverde; G M Mintenig; F V Sepúlveda
Journal:  Cell       Date:  1992-10-02       Impact factor: 41.582

2.  The detection and classification of membrane-spanning proteins.

Authors:  P Klein; M Kanehisa; C DeLisi
Journal:  Biochim Biophys Acta       Date:  1985-05-28

3.  Cloning by gene amplification of two loci conferring multiple drug resistance in Saccharomyces.

Authors:  G Leppert; R McDevitt; S C Falco; T K Van Dyk; M B Ficke; J Golin
Journal:  Genetics       Date:  1990-05       Impact factor: 4.562

4.  Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum.

Authors:  S J Foote; D E Kyle; R K Martin; A M Oduola; K Forsyth; D J Kemp; A F Cowman
Journal:  Nature       Date:  1990-05-17       Impact factor: 49.962

5.  PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1.

Authors:  E Balzi; M Wang; S Leterme; L Van Dyck; A Goffeau
Journal:  J Biol Chem       Date:  1994-01-21       Impact factor: 5.157

6.  Reversal of chloroquine resistance in Plasmodium falciparum by verapamil.

Authors:  S K Martin; A M Oduola; W K Milhous
Journal:  Science       Date:  1987-02-20       Impact factor: 47.728

7.  Mutations in the yeast PDR3, PDR4, PDR7 and PDR9 pleiotropic (multiple) drug resistance loci affect the transcript level of an ATP binding cassette transporter encoding gene, PDR5.

Authors:  D Dexter; W S Moye-Rowley; A L Wu; J Golin
Journal:  Genetics       Date:  1994-02       Impact factor: 4.562

8.  Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

Authors:  A Fojo; S Akiyama; M M Gottesman; I Pastan
Journal:  Cancer Res       Date:  1985-07       Impact factor: 12.701

9.  Interaction of the yeast pleiotropic drug resistance genes PDR1 and PDR5.

Authors:  S Meyers; W Schauer; E Balzi; M Wagner; A Goffeau; J Golin
Journal:  Curr Genet       Date:  1992-05       Impact factor: 3.886

10.  Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.

Authors:  C M Wilson; A E Serrano; A Wasley; M P Bogenschutz; A H Shankar; D F Wirth
Journal:  Science       Date:  1989-06-09       Impact factor: 47.728
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  14 in total

1.  Multiple-drug-resistance phenomenon in the yeast Saccharomyces cerevisiae: involvement of two hexose transporters.

Authors:  A Nourani; M Wesolowski-Louvel; T Delaveau; C Jacq; A Delahodde
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

Review 2.  Antifungal activity of nonantifungal drugs.

Authors:  J Afeltra; P E Verweij
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2003-06-26       Impact factor: 3.267

Review 3.  Multidrug resistance in fungi.

Authors:  Kailash Gulshan; W Scott Moye-Rowley
Journal:  Eukaryot Cell       Date:  2007-09-14

4.  The Rim101 pathway is involved in Rsb1 expression induced by altered lipid asymmetry.

Authors:  Mika Ikeda; Akio Kihara; Aki Denpoh; Yasuyuki Igarashi
Journal:  Mol Biol Cell       Date:  2008-02-20       Impact factor: 4.138

5.  Regulation of transcription factor Pdr1p function by an Hsp70 protein in Saccharomyces cerevisiae.

Authors:  T C Hallstrom; D J Katzmann; R J Torres; W J Sharp; W S Moye-Rowley
Journal:  Mol Cell Biol       Date:  1998-03       Impact factor: 4.272

6.  The signaling interface of the yeast multidrug transporter Pdr5 adopts a cis conformation, and there are functional overlap and equivalence of the deviant and canonical Q-loop residues.

Authors:  Neeti Ananthaswamy; Robert Rutledge; Zuben E Sauna; Suresh V Ambudkar; Elliot Dine; Emily Nelson; Di Xia; John Golin
Journal:  Biochemistry       Date:  2010-06-01       Impact factor: 3.162

Review 7.  The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transporters.

Authors:  John Golin; Suresh V Ambudkar
Journal:  Biochem J       Date:  2015-05-01       Impact factor: 3.857

8.  Expression of an ATP-binding cassette transporter-encoding gene (YOR1) is required for oligomycin resistance in Saccharomyces cerevisiae.

Authors:  D J Katzmann; T C Hallstrom; M Voet; W Wysock; J Golin; G Volckaert; W S Moye-Rowley
Journal:  Mol Cell Biol       Date:  1995-12       Impact factor: 4.272

9.  Enhancing drug accumulation in Saccharomyces cerevisiae by repression of pleiotropic drug resistance genes with chimeric transcription repressors.

Authors:  Alexander Stepanov; Karin C Nitiss; Geoffrey Neale; John L Nitiss
Journal:  Mol Pharmacol       Date:  2008-05-09       Impact factor: 4.436

10.  Combined phylogeny and neighborhood analysis of the evolution of the ABC transporters conferring multiple drug resistance in hemiascomycete yeasts.

Authors:  Marie-Line Seret; Julie F Diffels; André Goffeau; Philippe V Baret
Journal:  BMC Genomics       Date:  2009-10-01       Impact factor: 3.969
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