Literature DB >> 7840588

Biocidal action of chlorhexidine is annulled by nicotinic acid.

H Baker1, O Frank, B DeAngelis, E R Baker.   

Abstract

An analytical system comprising a bacterium and a protozoan was used to pinpoint the metabolic lesion whereby chlorhexidine (CLX) produced cell death. Nicotinic acid but not nicotinamide annulled the biocidal action of CLX. The results suggest that CLX may not permit bioconversion of nicotinamide to nicotinic acid to annul the growth inhibition induced by CLX.

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Year:  1994        PMID： 7840588      PMCID： PMC284762          DOI： 10.1128/AAC.38.10.2458

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Nicotinic acid and alcoholism [proceedings].

Authors:  H Baker; O Frank; M F Sorrell
Journal:  Bibl Nutr Dieta       Date:  1976

2.  Microbiological assay methods for vitamins.

Authors:  H BAKER; H SOBOTKA
Journal:  Adv Clin Chem       Date:  1962       Impact factor: 5.394

3.  Lesions in folic acid metabolism induced by primidone.

Authors:  H BAKER; O FRANK; S H HUTNER; S AARONSON; H ZIFFER; H SOBOTKA
Journal:  Experientia       Date:  1962-05-15

Review 4.  Use of niacin as a drug.

Authors:  J R DiPalma; W S Thayer
Journal:  Annu Rev Nutr       Date:  1991       Impact factor: 11.848

Review 5.  Use of microorganisms for the study of drug metabolism: an update.

Authors:  A M Clark; C D Hufford
Journal:  Med Res Rev       Date:  1991-09       Impact factor: 12.944

6.  Inhibition of mobility of Tetrahymena pyriformis by certain new local anaesthetics: an alternative in vitro approach to drug screening.

Authors:  D al-Saadi; W E Sneader; A J Baillie; N G Waton
Journal:  Pharmazie       Date:  1993-08       Impact factor: 1.267

7.  Inhibition by nicotinic acid of hepatic steatosis and alcohol dehydrogenase in ethanol-treated rats.

Authors:  H Baker; A Luisada-Opper; M F Sorrell; A D Thomson; O Frank
Journal:  Exp Mol Pathol       Date:  1973-08       Impact factor: 3.362

8.  A 6-month home usage trial of a 1% chlorhexidine toothpaste (1). Effects on plaque, gingivitis, calculus and toothstaining.

Authors:  R Yates; S Jenkins; R Newcombe; W Wade; J Moran; M Addy
Journal:  J Clin Periodontol       Date:  1993-02       Impact factor: 8.728

9.  In vitro antiplaque activity of octenidine dihydrochloride (WIN 41464-2) against preformed plaques of selected oral plaque-forming microorganisms.

Authors:  A M Slee; J R O'Connor
Journal:  Antimicrob Agents Chemother       Date:  1983-03       Impact factor: 5.191

10.  Metabolic deficiencies in protozoa induced by thalidomide.

Authors:  O FRANK; H BAKER; H ZIFFER; S AARONSON; S H HUTNER; C M LEEVY
Journal:  Science       Date:  1963-01-11       Impact factor: 47.728
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  1 in total

1.  Antioxidant survey to assess antagonism to redox stress using a prokaryotic and an eukaryotic system.

Authors:  H Baker; B DeAngelis; O Frank; M Khalil; S H Hutner; E R Baker
Journal:  Experientia       Date:  1996-06-15
  1 in total

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