Literature DB >> 13959249

Metabolic deficiencies in protozoa induced by thalidomide.

O FRANK, H BAKER, H ZIFFER, S AARONSON, S H HUTNER, C M LEEVY.   

Abstract

Thalidomide inhibits growth of some protozoa. This inhibition was counteracted by nicotinic acid, nicotinamide, nicotinamide adenine dinucleotide, and vitamin K(1). The mechanism of toxicity may be an interference of cellular oxidation. A protozoan test system is useful for studying the potential "side actions" of drugs in higher animals and man.

Entities:  

Keywords:  EUGLENA; MASTIGOPHORA; TETRAHYMENA; THALIDOMIDE

Mesh：

Substances：

Year:  1963        PMID： 13959249     DOI： 10.1126/science.139.3550.110

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  5 in total

1.  PERIPHERAL NEUROPATHY OF THE ALCOHOLIC: I, AETIOLOGICAL ROLE OF ANEURIN AND OTHER B-COMPLEX VITAMINS.

Authors:  J FENNELLY; O FRANK; H BAKER; C M LEEVY
Journal:  Br Med J       Date:  1964-11-21

2.  [ON THE FORMAL GENESIS OF EAR ABNORMALITIES IN THALIDOMIDE EMBRYOPATHY].

Authors:  C J PARTSCH; H MAURER
Journal:  Arch Ohren Nasen Kehlkopfheilkd       Date:  1963-12-09

3.  Early foetal thrombosis induced by thalidomide in mouse: possible explanation for teratogenicity.

Authors:  C Petter
Journal:  Experientia       Date:  1977-10-15

4.  Nitric oxide mitigates thalidomide-induced abnormalities during germination and development of fennel seeds.

Authors:  Akila Swaminathan; Koneti Brahma Kalyani; Senthil Kumar Sudhagar; Srinivasan Bhuvaneswari; S Thupali Nagalatha; T Leon Stephan Raj; Venil N Sumantran; Suvro Chatterjee
Journal:  Toxicol Res (Camb)       Date:  2021-07-30       Impact factor: 2.680

5.  Biocidal action of chlorhexidine is annulled by nicotinic acid.

Authors:  H Baker; O Frank; B DeAngelis; E R Baker
Journal:  Antimicrob Agents Chemother       Date:  1994-10       Impact factor: 5.191
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.