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Literature DB >> 7838139

Citrate inhibition of rat-kidney cortex phosphofructokinase.

M M Sola¹, F J Oliver, R Salto, M Gutiérrez, A Vargas.

Abstract

The regulatory properties of citrate on the activity of phosphofructokinase (PFK) purified from rat-kidney cortex has been studied. Citrate produces increases in the K0.5 for Fru-6-P and in the Hill coefficient as well as a decrease in the Vmax of the reaction without affecting the kinetic parameters for ATP as substrate. ATP potentiates synergistically the effects of citrate as an inhibitor of the enzyme. Fru-2,6-P2 and AMP at concentrations equal to Ka were not able to completely prevent citrate inhibition of the enzyme. Physiological concentrations of ATP and citrate produce a strong inhibition of renal PFK suggesting that may participate in the control of glycolysis in vivo.

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Year: 1994 PMID： 7838139 DOI： 10.1007/bf00926514

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

28 in total

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4 in total

1. Endothelial inflammation induced by excess glucose is associated with cytosolic glucose 6-phosphate but not increased mitochondrial respiration.

Authors: I R Sweet; M Gilbert; E Maloney; D M Hockenbery; M W Schwartz; F Kim
Journal: Diabetologia Date: 2009-02-14 Impact factor: 10.122