Literature DB >> 7830716

Expression of human poly(ADP-ribose) polymerase in Saccharomyces cerevisiae.

M A Collinge1, F R Althaus.   

Abstract

The coding sequence for human poly(ADP-ribose) polymerase was expressed inducibly in Saccharomyces cerevisiae from a low-copy-number plasmid vector. Cell free extracts of induced cells had poly(ADP-ribose) polymerase activity when assayed under standard conditions; activity could not be detected in noninduced cell extracts. Induced cells formed poly(ADP-ribose) in vivo, and levels of these polymers increased when cells were treated with the alkylating agent N-methyl-N'-nitro-N- nitrosoguanidine (MNNG). The cytotoxicity of this agent was increased in induced cells, and in vivo labelling with [3H]adenine further decreased their viability. Increased levels of poly(ADP-ribose) found in cells treated with the alkylating agent were not accompanied by lowering of the NAD concentration.

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Year:  1994        PMID： 7830716     DOI： 10.1007/bf00297275

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  37 in total

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3.  An affinity matrix for the purification of poly(ADP-ribose) glycohydrolase.

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4.  A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli.

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5.  Characterisation of poly(ADP-Rib) polymerase activity in nuclei from the slime mould Dictyostelium discoideum.

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6.  Optimal extraction conditions for high-performance liquid chromatographic determination of nucleotides in yeast.

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7.  Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA.

Authors:  J Ménissier-de Murcia; M Molinete; G Gradwohl; F Simonin; G de Murcia
Journal:  J Mol Biol       Date:  1989-11-05       Impact factor: 5.469

8.  Presence of poly (ADP-ribose) polymerase and poly (ADP-ribose) glycohydrolase in the dinoflagellate Crypthecodinium cohnii.

Authors:  E Werner; S Sohst; F Gropp; D Simon; H Wagner; H Kröger
Journal:  Eur J Biochem       Date:  1984-02-15

9.  Sequences that regulate the divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae.

Authors:  M Johnston; R W Davis
Journal:  Mol Cell Biol       Date:  1984-08       Impact factor: 4.272

10.  DNA fragmentation and NAD depletion. Their relation to the turnover of endogenous mono(ADP-ribosyl) and poly(ADP-ribosyl) proteins.

Authors:  K Wielckens; A Schmidt; E George; R Bredehorst; H Hilz
Journal:  J Biol Chem       Date:  1982-11-10       Impact factor: 5.157
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  7 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

3.  Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis.

Authors:  Z Herceg; Z Q Wang
Journal:  Mol Cell Biol       Date:  1999-07       Impact factor: 4.272

4.  Purification and cDNA cloning of maize Poly(ADP)-ribose polymerase.

Authors:  P B Mahajan; Z Zuo
Journal:  Plant Physiol       Date:  1998-11       Impact factor: 8.340

5.  Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice.

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Review 7.  Exploring absent protein function in yeast: assaying post translational modification and human genetic variation.

Authors:  Christina S Moesslacher; Johanna M Kohlmayr; Ulrich Stelzl
Journal:  Microb Cell       Date:  2021-07-02
  7 in total

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