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Literature DB >> 782907

Localization of peroxidase activity in Trypanosoma cruzi microbodies.

R Docampo, J F de Boiso, A Boveris, A O Stoppani.

Abstract

Electron microscopic observation of Trypanosoma cruzi epimastigotes reveals the presence of microbody-like structures (microperoxisomes) in which 3,3'-diaminobenzidine (DAB) is peroxidized to electron-opaque material. The role of peroxidase in DAB peroxidation is supported by the enzyme demonstration in disrupted epimastigotes and the microbody-containing cell fractions.

Entities: Chemical Disease Species

Mesh：

Substances：
Peroxidases
Catalase

Year: 1976 PMID： 782907 DOI： 10.1007/bf01933918

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

22 in total

1. Studies on the metabolism of the protozoa. 4. Metabolism of the parasitic flagellate Strigomonas oncopelti.

Authors: J F RYLEY
Journal: Biochem J Date: 1955-03 Impact factor: 3.857

2. Enzyme-substrate compounds.

Authors: B CHANCE
Journal: Adv Enzymol Relat Subj Biochem Date: 1951

Review 3. Microperoxisomes.

Authors: A B Novikoff; P M Novikoff
Journal: J Histochem Cytochem Date: 1973-11 Impact factor: 2.479

4. [Ultrastructure of Trypanosoma cruzi with scanning and transmission electromicroscopy].

Authors: J F de Boiso; R Docampo; A O Stoppani
Journal: Rev Asoc Argent Microbiol Date: 1974 Sep-Dec

5. Visualization of peroxisomes (microbodies) and mitochondria with diaminobenzidine.

Authors: A B Novikoff; S Goldfischer
Journal: J Histochem Cytochem Date: 1969-10 Impact factor: 2.479

6. Further observations on the peroxidatic activities of microbodies (Peroxisomes).

Authors: S Goldfischer; E Essner
Journal: J Histochem Cytochem Date: 1969-10 Impact factor: 2.479

7. The fine structure of different bloodstream forms of Trypanosoma cruzi.

Authors: T A Maria; W Tafuri; Z Brener
Journal: Ann Trop Med Parasitol Date: 1972-12

8. Evidence for the presence of two phosphorylation sites in mitochondria isolated from the trypanosomatid hemoflagellate, Crithidia fasciculata.

Authors: J P Kusel; B T Storey
Journal: Biochem Biophys Res Commun Date: 1972-01-31 Impact factor: 3.575

9. The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.

Authors: R C Graham; M J Karnovsky
Journal: J Histochem Cytochem Date: 1966-04 Impact factor: 2.479

10. Cytochemical localization of peroxidatic activity of catalase in rat hepatic microbodies (peroxisomes).

Authors: H D Fahimi
Journal: J Cell Biol Date: 1969-11 Impact factor: 10.539

11 in total

1. Ultrastructural alterations and peroxide formation induced by naphthoquinones in different stages of Trypanosoma cruzi.

Authors: R Docampo; W De Souza; F S Cruz; I Roitman; B Cover; W E Gutteridge
Journal: Z Parasitenkd Date: 1978-11-27

Localization of peroxidase activity in Trypanosoma cruzi microbodies.

1. Studies on the metabolism of the protozoa. 4. Metabolism of the parasitic flagellate Strigomonas oncopelti.

2. Enzyme-substrate compounds.

Review 3. Microperoxisomes.

4. [Ultrastructure of Trypanosoma cruzi with scanning and transmission electromicroscopy].

5. Visualization of peroxisomes (microbodies) and mitochondria with diaminobenzidine.

6. Further observations on the peroxidatic activities of microbodies (Peroxisomes).

7. The fine structure of different bloodstream forms of Trypanosoma cruzi.

8. Evidence for the presence of two phosphorylation sites in mitochondria isolated from the trypanosomatid hemoflagellate, Crithidia fasciculata.

9. The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.

10. Cytochemical localization of peroxidatic activity of catalase in rat hepatic microbodies (peroxisomes).

1. Ultrastructural alterations and peroxide formation induced by naphthoquinones in different stages of Trypanosoma cruzi.

2. Hydrogen peroxide generation in Trypanosoma cruzi.

3. Fine structure and cytochemistry of peroxisomes (microbodies) Leptomonas samueli.

4. Deficient metabolic utilization of hydrogen peroxide in Trypanosoma cruzi.

5. Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum.

6. Growth of Trypanosoma cruzi in a cloned macrophage cell line and in a variant defective in oxygen metabolism.

7. Effect of beta-lapachone on superoxide anion and hydrogen peroxide production in Trypanosoma cruzi.

8. Macrophage oxygen-dependent antimicrobial activity. I. Susceptibility of Toxoplasma gondii to oxygen intermediates.

9. Macrophage oxygen-dependent antimicrobial activity. IV. Role of endogenous scavengers of oxygen intermediates.

10. Inhibition of glutathione synthesis as a chemotherapeutic strategy for trypanosomiasis.