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Literature DB >> 20323

Hydrogen peroxide generation in Trypanosoma cruzi.

Abstract

Homogenates from T. cruzi epimastigotes produced 3.4 pmoles H2O2/min 10(6) cells, as detected by the cytochrome c peroxidase assay. Addition of NADH or NADPH increased H2O2 production by a factor of 3 and 5, respectively. When supplemented with NADH and NADPH, the mitochondrial, microsomal and supernatant fractions produced H2O2, the soluble fraction and the mitochondrial membranes being apparently the main generators of H2O2. The epimastigote homogenates showed cyanide-sensitive superoxide dismutase activity, equivalent to 0.28 microgram bovine superoxide dismutase per mg homogenate protein.

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Year: 1977 PMID： 20323 DOI： 10.1007/BF01920148

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

13 in total

1. Inhibition of the respiration of Trypanosoma rhodesiense by thiols.

Authors: J D FULTON; D F SPOONER
Journal: Biochem J Date: 1956-07 Impact factor: 3.857

2. Oxygen poisoning and x-irradiation: a mechanism in common.

Authors: R GERSCHMAN; D L GILBERT; S W NYE; P DWYER; W O FENN
Journal: Science Date: 1954-05-07 Impact factor: 47.728

3. Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria.

Authors: E Cadenas; A Boveris; C I Ragan; A O Stoppani
Journal: Arch Biochem Biophys Date: 1977-04-30 Impact factor: 4.013

4. Determination of serum proteins by means of the biuret reaction.

Authors: A G GORNALL; C J BARDAWILL; M M DAVID
Journal: J Biol Chem Date: 1949-02 Impact factor: 5.157

5. Evaluation of the horseradish peroxidase-scopoletin method for the measurement of hydrogen peroxide formation in biological systems.

Authors: A Boveris; E Martino; A O Stoppani
Journal: Anal Biochem Date: 1977-05-15 Impact factor: 3.365

6. [Metabolic changes in diskinetoplastic Trypanosoma cruzi by ethidium bromide action].

Authors: R Docampo; J F de Boiso; A O Stoppani
Journal: Medicina (B Aires) Date: 1974 Sep-Oct Impact factor: 0.653

7. H2O2 production and cytochrome c peroxidase activity in mitochondria isolated from the trypanosomatid hemoflagellate Crithidia fasciculata.

Authors: J P Kusel; A Boveris; B T Storey
Journal: Arch Biochem Biophys Date: 1973-10 Impact factor: 4.013

Review 8. Superoxide dismutases.

Authors: I Fridovich
Journal: Adv Enzymol Relat Areas Mol Biol Date: 1974

9. Microsomal hemoproteins in Trypanosoma cruzi.

Authors: J F De Boiso; A O Stoppani
Journal: Proc Soc Exp Biol Med Date: 1971-01

10. The cellular production of hydrogen peroxide.

Authors: A Boveris; N Oshino; B Chance
Journal: Biochem J Date: 1972-07 Impact factor: 3.857

12 in total

1. Ultrastructural alterations and peroxide formation induced by naphthoquinones in different stages of Trypanosoma cruzi.

Authors: R Docampo; W De Souza; F S Cruz; I Roitman; B Cover; W E Gutteridge
Journal: Z Parasitenkd Date: 1978-11-27

2. Role of Trypanosoma cruzi peroxiredoxins in mitochondrial bioenergetics.

Authors: Eduardo de Figueiredo Peloso; Simone Cespedes Vitor; Luis Henrique Gonzaga Ribeiro; María Dolores Piñeyro; Carlos Robello; Fernanda Ramos Gadelha
Journal: J Bioenerg Biomembr Date: 2011-07-06 Impact factor: 2.945

3. On the mechanism of killing of Trypanosoma cruzi by human polymorphonuclear leukocytes.

Authors: R L Cardoni; E H de Titto; R Docampo
Journal: Experientia Date: 1985-01-15

4. A comparative assessment of mitochondrial function in epimastigotes and bloodstream trypomastigotes of Trypanosoma cruzi.

Authors: Renata L S Gonçalves; Rubem F S Menna Barreto; Carla R Polycarpo; Fernanda R Gadelha; Solange L Castro; Marcus F Oliveira
Journal: J Bioenerg Biomembr Date: 2011-11-12 Impact factor: 2.945