Literature DB >> 7828145

Amplification of chromosome subregion 12p11.2-p12.1 in a metastasis of an i(12p)-negative seminoma: relationship to tumor progression?

R F Suijkerbuijk1, R J Sinke, D E Weghuis, L Roque, A Forus, F Stellink, A Siepman, C van de Kaa, J Soares, A Geurts van Kessel.   

Abstract

Cytogenetic analysis of a metastasis of a human testicular germ cell tumor (seminoma) revealed multiple numerical and structural anomalies, including an abnormally banding region (ABR) present on the short arm of one of the chromosome 12 homologs. Fluorescence in situ- and comparative genomic hybridization experiments revealed that the ABR results from the amplification of 12p11.2-p12.1 derived sequences. We speculate that this particular region may harbor gene(s) relevant for testicular germ cell tumor progression.

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Year:  1994        PMID： 7828145     DOI： 10.1016/0165-4608(94)90082-5

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  6 in total

1.  Restricted 12p amplification and RAS mutation in human germ cell tumors of the adult testis.

Authors:  H Roelofs; M C Mostert; K Pompe; G Zafarana; M van Oorschot; R J van Gurp; A J Gillis; H Stoop; B Beverloo; J W Oosterhuis; C Bokemeyer; L H Looijenga
Journal:  Am J Pathol       Date:  2000-10       Impact factor: 4.307

Review 2.  DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies.

Authors:  S Knuutila; A M Björkqvist; K Autio; M Tarkkanen; M Wolf; O Monni; J Szymanska; M L Larramendy; J Tapper; H Pere; W El-Rifai; S Hemmer; V M Wasenius; V Vidgren; Y Zhu
Journal:  Am J Pathol       Date:  1998-05       Impact factor: 4.307

Review 3.  New insights into the pathology and molecular biology of human germ cell tumors.

Authors:  Friedemann Honecker; J Wolter Oosterhuis; Frank Mayer; Jörg Thomas Hartmann; Carsten Bokemeyer; Leendert H J Looijenga
Journal:  World J Urol       Date:  2004-03-20       Impact factor: 4.226

4.  Pathogenesis of axonal dystrophy and demyelination in alphaA-crystallin-expressing transgenic mice.

Authors:  A F Van Rijk; M A M Sweers; G F M Merkx; M Lammens; H Bloemendal
Journal:  Int J Exp Pathol       Date:  2003-04       Impact factor: 1.925

5.  Molecular cytogenetic analysis of adult testicular germ cell tumours and identification of regions of consensus copy number change.

Authors:  B Summersgill; H Goker; S Weber-Hall; R Huddart; A Horwich; J Shipley
Journal:  Br J Cancer       Date:  1998       Impact factor: 7.640

6.  Chromosomal imbalances associated with carcinoma in situ and associated testicular germ cell tumours of adolescents and adults.

Authors:  B Summersgill; P Osin; Y J Lu; R Huddart; J Shipley
Journal:  Br J Cancer       Date:  2001-07-20       Impact factor: 7.640
  6 in total

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