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Literature DB >> 7826343

Thyroid hormone treatment alters phospholipid composition and membrane fluidity of rat brain mitochondria.

Abstract

We examined effects of graded doses of thyroid hormones 3,3', 5-tri-iodo-L-thyronine (T3) and L-thyroxine (T4) on the lipid composition of rat brain mitochondria. Neither hormone significantly affected the mitochondrial cholesterol or total phospholipid content, but did increase phosphatidylethanolamine (PE) at the expense of phosphatidylserine (PS), phosphatidylinositol (PI) and phosphatidylcholine (PC). The phosphatidic acid (PA) content was also elevated, suggesting enhanced phospholipid turnover. Changes in sphingomyelin (SPM) and diphosphatidylglycerol (DPG) were minimal. Mitochondrial membrane fluidity also increased after thyroid-hormone treatment, and the increase was closely correlated with PC/PE and SPM/PE molar ratios.

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Year: 1995 PMID： 7826343 PMCID： PMC1136425 DOI： 10.1042/bj3050029

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

19 in total

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13 in total

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2. Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts.

Authors: Rui Wu; Zeming Wu; Xianhui Wang; Pengcheng Yang; Dan Yu; Chunxia Zhao; Guowang Xu; Le Kang
Journal: Proc Natl Acad Sci U S A Date: 2012-02-10 Impact factor: 11.205

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Authors: Michael A Kiebish; Xianlin Han; Hua Cheng; Jeffrey H Chuang; Thomas N Seyfried
Journal: Lipids Date: 2008-06-17 Impact factor: 1.880

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Authors: Hiren R Modi; Surendra S Katyare
Journal: J Membr Biol Date: 2009-11-17 Impact factor: 1.843

5. Ageing-induced alterations in lipid/phospholipid profiles of rat brain and liver mitochondria: implications for mitochondrial energy-linked functions.

Authors: Hiren R Modi; Surendra S Katyare; Minal A Patel
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Authors: Hiren R Modi; Samir P Patel; Surendra S Katyare; Minal Patel
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