PURPOSE: To assess the utility of magnetic resonance (MR) flow quantification in the evaluation of suspected carotid artery stenosis. MATERIALS AND METHODS: Fifty-five patients referred for angiography and 10 healthy volunteers underwent Doppler ultrasound, three-dimensional time-of-flight MR angiography, and MR phase-contrast flow quantification to measure peak systolic velocity (PSV) and volumetric flow rate (VFR) in the common and internal carotid arteries distal to the stenosis. RESULTS: PSV and VFR were significantly lower in the severely (> or = 70%) stenosed internal carotid arteries (P < .05). The VFR ratio (internal carotid artery-common carotid artery) achieved 91% overall accuracy for detection of severe stenosis. Combination of flow data with results of MR angiography yielded sensitivity of 100% (95% confidence interval, 78%-100%) with a modest loss in specificity. Doppler and MR measurements of PSV in the common carotid artery showed significant correlation: volunteers, r = .73; patients, r = .64. CONCLUSION: MR flow quantification provides information about the hemodynamic significance of carotid stenosis. As an adjunct to MR angiography, it may be useful in enabling differentiation of occlusions from critical stenoses.
PURPOSE: To assess the utility of magnetic resonance (MR) flow quantification in the evaluation of suspected carotid artery stenosis. MATERIALS AND METHODS: Fifty-five patients referred for angiography and 10 healthy volunteers underwent Doppler ultrasound, three-dimensional time-of-flight MR angiography, and MR phase-contrast flow quantification to measure peak systolic velocity (PSV) and volumetric flow rate (VFR) in the common and internal carotid arteries distal to the stenosis. RESULTS: PSV and VFR were significantly lower in the severely (> or = 70%) stenosed internal carotid arteries (P < .05). The VFR ratio (internal carotid artery-common carotid artery) achieved 91% overall accuracy for detection of severe stenosis. Combination of flow data with results of MR angiography yielded sensitivity of 100% (95% confidence interval, 78%-100%) with a modest loss in specificity. Doppler and MR measurements of PSV in the common carotid artery showed significant correlation: volunteers, r = .73; patients, r = .64. CONCLUSION: MR flow quantification provides information about the hemodynamic significance of carotid stenosis. As an adjunct to MR angiography, it may be useful in enabling differentiation of occlusions from critical stenoses.
Authors: K J van Everdingen; L J Kappelle; C J Klijn; W P Mali; J van Der Grond Journal: J Neurol Neurosurg Psychiatry Date: 2001-03 Impact factor: 10.154
Authors: Da Wang; Jiaxin Shao; Stanislas Rapacchi; Matthew J Middione; Daniel B Ennis; Peng Hu Journal: Magn Reson Med Date: 2014-02-14 Impact factor: 4.668
Authors: Francesco Secchi; Caterina Beatrice Monti; Davide Capra; Renato Vitale; Daniela Mazzaccaro; Michele Conti; Ning Jin; Daniel Giese; Giovanni Nano; Francesco Sardanelli; Massimiliano M Marrocco-Trischitta Journal: Tomography Date: 2021-09-28