Literature DB >> 7824170

Transforming growth factor-beta-2 (TGF-beta 2) is associated with mature rat neuromuscular junctions.

I S McLennan1, K Koishi.   

Abstract

The localisation of transforming growth factor-beta-2 (TGF-beta 2) in skeletal muscles was investigated with immunohistochemistry. In neonates, TGF-beta 2 was distributed throughout the muscle fibres but as the fibres matured TGF-beta 2 became restricted to the circumference of a small subpopulation of nuclei. These nuclei were judged to be the subsynaptic nuclei as they lay beneath the plasmalemma and were associated with alpha-bungarotoxin-labelled neuromuscular junctions. These observations point to TGF-beta 2 being either a trophic factor for mature motoneurones or an autocrine regulator of synaptic protein production.

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Year:  1994        PMID： 7824170     DOI： 10.1016/0304-3940(94)90889-3

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  5 in total

1.  Identification of Erbin interlinking MuSK and ErbB2 and its impact on acetylcholine receptor aggregation at the neuromuscular junction.

Authors:  Luca Simeone; Marion Straubinger; Muhammad Amir Khan; Nancy Nalleweg; Tatiana Cheusova; Said Hashemolhosseini
Journal:  J Neurosci       Date:  2010-05-12       Impact factor: 6.167

Review 2.  TGF-β Family Signaling in Mesenchymal Differentiation.

Authors:  Ingo Grafe; Stefanie Alexander; Jonathan R Peterson; Taylor Nicholas Snider; Benjamin Levi; Brendan Lee; Yuji Mishina
Journal:  Cold Spring Harb Perspect Biol       Date:  2018-05-01       Impact factor: 10.005

3.  TGF-beta2 alters the characteristics of the neuromuscular junction by regulating presynaptic quantal size.

Authors:  Sitt Wai Fong; Ian S McLennan; Andrew McIntyre; Jayne Reid; Kathleen I J Shennan; Guy S Bewick
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-12       Impact factor: 11.205

4.  Localization of transforming growth factor beta in association with neuromuscular junctions in adult human muscle.

Authors:  M Toepfer; P Fischer; A Abicht; H Lochmüller; D Pongratz; W Müller-Felber
Journal:  Cell Mol Neurobiol       Date:  1999-04       Impact factor: 5.046

5.  Loss of transforming growth factor-beta 2 leads to impairment of central synapse function.

Authors:  Katharina Heupel; Vardanush Sargsyan; Jaap J Plomp; Michael Rickmann; Frédérique Varoqueaux; Weiqi Zhang; Kerstin Krieglstein
Journal:  Neural Dev       Date:  2008-10-14       Impact factor: 3.842
  5 in total

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