Literature DB >> 7821744

On the pathogenesis of IDDM.

J Nerup1, T Mandrup-Poulsen, S Helqvist, H U Andersen, F Pociot, J I Reimers, B G Cuartero, A E Karlsen, U Bjerre, T Lorenzen.   

Abstract

A model of the pathogenesis of insulin-dependent diabetes mellitus, i.e. the initial phase of beta-cell destruction, is proposed: in a cascade-like fashion efficient antigen presentation, unbalanced cytokine, secretion and poor beta-cell defence result in beta-cell destruction by toxic free radicals (O2- and nitric oxide) produced by the beta cells themselves. This entire process is under polygenetic control.

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Year:  1994        PMID： 7821744     DOI： 10.1007/bf00400830

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  59 in total

1.  Interleukin 1 beta increases the cytosolic free sodium concentration in isolated rat islets of Langerhans.

Authors:  S Helqvist; P N Bouchelouche; J Johannesen; J Nerup
Journal:  Scand J Immunol       Date:  1990-07       Impact factor: 3.487

Review 2.  Biochemical and molecular actions of interleukin-1 on pancreatic beta-cells.

Authors:  S Sandler; D L Eizirik; C Svensson; E Strandell; M Welsh; N Welsh
Journal:  Autoimmunity       Date:  1991       Impact factor: 2.815

Review 3.  Nitric oxide synthase structure and mechanism.

Authors:  M A Marletta
Journal:  J Biol Chem       Date:  1993-06-15       Impact factor: 5.157

4.  What are the types and cellular sources of free radicals in the pathogenesis of type 1 (insulin-dependent) diabetes mellitus?

Authors:  T Mandrup-Poulsen; J A Corbett; M L McDaniel; J Nerup
Journal:  Diabetologia       Date:  1993-05       Impact factor: 10.122

5.  Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans.

Authors:  T Mandrup-Poulsen; K Bendtzen; J Nerup; C A Dinarello; M Svenson; J H Nielsen
Journal:  Diabetologia       Date:  1986-01       Impact factor: 10.122

6.  Characterization of pancreatic islet cell infiltrates in NOD mice: effect of cell transfer and transgene expression.

Authors:  L A O'Reilly; P R Hutchings; P R Crocker; E Simpson; T Lund; D Kioussis; F Takei; J Baird; A Cooke
Journal:  Eur J Immunol       Date:  1991-05       Impact factor: 5.532

7.  Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

Authors:  J S Beckman; T W Beckman; J Chen; P A Marshall; B A Freeman
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

8.  Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats.

Authors:  R Kleemann; H Rothe; V Kolb-Bachofen; Q W Xie; C Nathan; S Martin; H Kolb
Journal:  FEBS Lett       Date:  1993-08-09       Impact factor: 4.124

9.  Polygenic control of autoimmune diabetes in nonobese diabetic mice.

Authors:  S Ghosh; S M Palmer; N R Rodrigues; H J Cordell; C M Hearne; R J Cornall; J B Prins; P McShane; G M Lathrop; L B Peterson
Journal:  Nat Genet       Date:  1993-08       Impact factor: 38.330

10.  The inducible nitric oxide synthase gene, Nos2, maps to mouse chromosome 11.

Authors:  I C Gerling; A E Karlsen; H D Chapman; H U Andersen; E Boel; J M Cunningham; J Nerup; E H Leiter
Journal:  Mamm Genome       Date:  1994-05       Impact factor: 2.957
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  38 in total

Review 1.  Genes affecting β-cell function in type 1 diabetes.

Authors:  Tina Fløyel; Simranjeet Kaur; Flemming Pociot
Journal:  Curr Diab Rep       Date:  2015-11       Impact factor: 4.810

Review 2.  Is insulin signaling molecules misguided in diabetes for ubiquitin-proteasome mediated degradation?

Authors:  Muthuswamy Balasubramanyam; Rangasamy Sampathkumar; Viswanathan Mohan
Journal:  Mol Cell Biochem       Date:  2005-07       Impact factor: 3.396

Review 3.  Candidate genes expressed in human islets and their role in the pathogenesis of type 1 diabetes.

Authors:  Joachim Storling; Caroline Anna Brorsson
Journal:  Curr Diab Rep       Date:  2013-10       Impact factor: 4.810

Review 4.  Novel biomarkers in type 1 diabetes.

Authors:  Yulan Jin; Jin-Xiong She
Journal:  Rev Diabet Stud       Date:  2012-12-28

Review 5.  Do post-translational beta cell protein modifications trigger type 1 diabetes?

Authors:  Joachim Størling; Anne Julie Overgaard; Caroline Anna Brorsson; Francesco Piva; Claus Heiner Bang-Berthelsen; Claus Haase; Jørn Nerup; Flemming Pociot
Journal:  Diabetologia       Date:  2013-09-19       Impact factor: 10.122

6.  CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients.

Authors:  Tina Fløyel; Caroline Brorsson; Lotte B Nielsen; Michela Miani; Claus Heiner Bang-Berthelsen; Martin Friedrichsen; Anne Julie Overgaard; Lukas A Berchtold; Anna Wiberg; Pernille Poulsen; Lars Hansen; Silke Rosinger; Bernhard O Boehm; Ramesh Ram; Quang Nguyen; Munish Mehta; Grant Morahan; Patrick Concannon; Regine Bergholdt; Jens H Nielsen; Thomas Reinheckel; Matthias von Herrath; Allan Vaag; Decio Laks Eizirik; Henrik B Mortensen; Joachim Størling; Flemming Pociot
Journal:  Proc Natl Acad Sci U S A       Date:  2014-06-30       Impact factor: 11.205

7.  Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.

Authors:  A E Karlsen; P E Heding; H Frobøse; S G Rønn; M Kruhøffer; T F Orntoft; M Darville; D L Eizirik; F Pociot; J Nerup; T Mandrup-Poulsen; N Billestrup
Journal:  Diabetologia       Date:  2004-12-02       Impact factor: 10.122

8.  Posttranslational Protein Modifications in Type 1 Diabetes - Genetic Studies with PCMT1, the Repair Enzyme Protein Isoaspartate Methyltransferase (PIMT) Encoding Gene.

Authors:  Ana M Wägner; Paul Cloos; Regine Bergholdt; Stefanie Eising; Caroline Brorsson; Martin Stalhut; Stephan Christgau; Jørn Nerup; Flemming Pociot
Journal:  Rev Diabet Stud       Date:  2009-02-10

9.  Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity.

Authors:  T Gylvin; R Nolsøe; T Hansen; E M D Nielsen; R Bergholdt; A E Karlsen; N Billestrup; K Borch-Johnsen; O Pedersen; T Mandrup-Poulsen; J Nerup; F Pociot
Journal:  Diabetologia       Date:  2004-07-13       Impact factor: 10.122

10.  Approaches in type 1 diabetes research: A status report.

Authors:  Oindrila Raha; Subhankar Chowdhury; Samir Dasgupta; P Raychaudhuri; B N Sarkar; P Veer Raju; V R Rao
Journal:  Int J Diabetes Dev Ctries       Date:  2009-04
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