Literature DB >> 7688327

Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats.

R Kleemann1, H Rothe, V Kolb-Bachofen, Q W Xie, C Nathan, S Martin, H Kolb.   

Abstract

The inducible NO synthase (iNOS) was found to be expressed in pancreatic lesions of adult diabetes-prone BB rats. Pancreatic iNOS mRNA was detected by reverse transcriptase PCR in pancreatic RNA of adult diabetes-prone BB rats but not in normal Wistar rats, young diabetes-prone BB rats without insulitis or in diabetes-resistant BB rats. Immunohistochemistry of pancreatic sections using an iNOS-specific antiserum labeled the pancreas of adult diabetes-prone BB rats but not Wistar rats. Parallel staining for ED1-positive macrophages showed restriction of iNOS expression to areas of islet infiltration by macrophages. In conclusion, the data provide direct evidence for enhanced expression of inducible NO synthase in tissue lesions during the development of autoimmune diabetes.

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Year:  1993        PMID： 7688327     DOI： 10.1016/0014-5793(93)80954-s

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  29 in total

1.  Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity.

Authors:  M Shimabukuro; K Koyama; Y Lee; R H Unger
Journal:  J Clin Invest       Date:  1997-10-01       Impact factor: 14.808

Review 2.  Inducible nitric oxide synthase in human diseases.

Authors:  K D Kröncke; K Fehsel; V Kolb-Bachofen
Journal:  Clin Exp Immunol       Date:  1998-08       Impact factor: 4.330

Review 3.  The role of interleukin-1 in the pathogenesis of IDDM.

Authors:  T Mandrup-Poulsen
Journal:  Diabetologia       Date:  1996-09       Impact factor: 10.122

4.  Regulation of iNOS gene transcription by IL-1β and IFN-γ requires a coactivator exchange mechanism.

Authors:  Susan J Burke; Barrett L Updegraff; Rachel M Bellich; Matthew R Goff; Danhong Lu; Steven C Minkin; Michael D Karlstad; J Jason Collier
Journal:  Mol Endocrinol       Date:  2013-09-06

5.  Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.

Authors:  Toshihiro Tanioka; Yoshiaki Tamura; Makiko Fukaya; Shohei Shinozaki; Ji Mao; Minhye Kim; Nobuyuki Shimizu; Tadahiro Kitamura; Masao Kaneki
Journal:  J Biol Chem       Date:  2011-06-23       Impact factor: 5.157

6.  Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha.

Authors:  J P Maciejewski; C Selleri; T Sato; H J Cho; L K Keefer; C F Nathan; N S Young
Journal:  J Clin Invest       Date:  1995-08       Impact factor: 14.808

7.  Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats.

Authors:  Ricardo Valladares; Dhyana Sankar; Nan Li; Emily Williams; Kin-Kwan Lai; Asmaa Sayed Abdelgeliel; Claudio F Gonzalez; Clive H Wasserfall; Joseph Larkin; Desmond Schatz; Mark A Atkinson; Eric W Triplett; Josef Neu; Graciela L Lorca
Journal:  PLoS One       Date:  2010-05-06       Impact factor: 3.240

8.  Role for activating transcription factor 3 in stress-induced beta-cell apoptosis.

Authors:  Matthew G Hartman; Dan Lu; Mi-Lyang Kim; Gary J Kociba; Tala Shukri; Jean Buteau; Xiaozhong Wang; Wendy L Frankel; Denis Guttridge; Marc Prentki; Shane T Grey; David Ron; Tsonwin Hai
Journal:  Mol Cell Biol       Date:  2004-07       Impact factor: 4.272

Review 9.  The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells.

Authors:  D L Eizirik; M Flodström; A E Karlsen; N Welsh
Journal:  Diabetologia       Date:  1996-08       Impact factor: 10.122

10.  Antioxidant enzyme activity and mRNA expression in the islets of Langerhans from the BB/S rat model of type 1 diabetes and an insulin-producing cell line.

Authors:  Louise A Sigfrid; James M Cunningham; Neil Beeharry; L A Håkan Borg; Alma L Rosales Hernandez; Carina Carlsson; Adrian J Bone; Irene C Green
Journal:  J Mol Med (Berl)       Date:  2004-03-09       Impact factor: 4.599
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