OBJECTIVE: To compare vitamin B6 levels in rheumatoid arthritis (RA) patients and healthy control subjects. METHODS: We measured levels of vitamin B6 in 23 adults with well-controlled RA, and in 23 healthy control subjects matched for age, sex, race, and weight. RESULTS: Although plasma folate and vitamin B12 concentrations and erythrocyte B6 activity coefficients were similar in the patients and controls, plasma levels of pyridoxal-5'-phosphate (PLP) were lower in the RA patient group (mean +/- SD 46.1 +/- 48.1 versus 69.3 +/- 58.4 nmoles/liter; P < 0.004). In multivariate analyses, PLP was inversely associated with tumor necrosis factor alpha (TNF alpha) production by peripheral blood mononuclear cells (PBMC) (P < 0.001), after adjustment for age, pain score, erythrocyte sedimentation rate, and use of nonsteroidal antiinflammatory drugs. CONCLUSION: PLP levels are reduced in patients with RA. This reduction is associated with TNF alpha production by PBMC.
OBJECTIVE: To compare vitamin B6 levels in rheumatoid arthritis (RA) patients and healthy control subjects. METHODS: We measured levels of vitamin B6 in 23 adults with well-controlled RA, and in 23 healthy control subjects matched for age, sex, race, and weight. RESULTS: Although plasma folate and vitamin B12 concentrations and erythrocyte B6 activity coefficients were similar in the patients and controls, plasma levels of pyridoxal-5'-phosphate (PLP) were lower in the RApatient group (mean +/- SD 46.1 +/- 48.1 versus 69.3 +/- 58.4 nmoles/liter; P < 0.004). In multivariate analyses, PLP was inversely associated with tumor necrosis factor alpha (TNF alpha) production by peripheral blood mononuclear cells (PBMC) (P < 0.001), after adjustment for age, pain score, erythrocyte sedimentation rate, and use of nonsteroidal antiinflammatory drugs. CONCLUSION: PLP levels are reduced in patients with RA. This reduction is associated with TNF alpha production by PBMC.
Authors: Oana M Deac; James L Mills; Clair M Gardiner; Barry Shane; Louise Quinn; Øivind Midttun; Adrian McCann; Klaus Meyer; Per M Ueland; Ruzong Fan; Zhaohui Lu; Lawrence C Brody; Anne M Molloy Journal: J Nutr Date: 2016-08-03 Impact factor: 4.798
Authors: Refael Segal; Yehuda Baumoehl; Ori Elkayam; David Levartovsky; Irena Litinsky; Daphna Paran; Irena Wigler; Beni Habot; Arthur Leibovitz; Ben Ami Sela; Dan Caspi Journal: Rheumatol Int Date: 2003-04-29 Impact factor: 2.631
Authors: Youjin Je; Jung Eun Lee; Jing Ma; Xuehong Zhang; Eunyoung Cho; Bernard Rosner; Jacob Selhub; Charles S Fuchs; Jeffrey Meyerhardt; Edward Giovannucci Journal: Cancer Causes Control Date: 2013-01-23 Impact factor: 2.506