Literature DB >> 7818505

Purification and characterization of thyroid transcription factor 2.

D Civitareale1, A Saiardi, P Falasca.   

Abstract

Thyroid transcription factor 2 binds to the promoters of both thyroglobulin and thyroperoxidase genes, two markers of thyroid tissue differentiation, and its binding modulates the activity of both promoters. In this paper we describe the purification of thyroid transcription factor 2 essentially to homogeneity and demonstrate that it is a thyroid-specific DNA-binding protein. Furthermore, we provide a biochemical characterization suggesting that thyroid transcription factor 2 binds to DNA as a dimer and that it is a zinc-finger DNA-binding protein regulated in vitro by the redox state.

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Year:  1994        PMID： 7818505      PMCID： PMC1137428          DOI： 10.1042/bj3040981

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  25 in total

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5.  The role of the kappa enhancer and its binding factor NF-kappa B in the developmental regulation of kappa gene transcription.

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Review 6.  Redox control of transcription: sensors, response regulators, activators and repressors.

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7.  Cooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitro.

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8.  Insulin and insulin-like growth factor I regulate a thyroid-specific nuclear protein that binds to the thyroglobulin promoter.

Authors:  P Santisteban; A Acebrón; M Polycarpou-Schwarz; R Di Lauro
Journal:  Mol Endocrinol       Date:  1992-08

9.  Multiple mechanisms of interference between transformation and differentiation in thyroid cells.

Authors:  H Francis-Lang; M Zannini; M De Felice; M T Berlingieri; A Fusco; R Di Lauro
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10.  The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain.

Authors:  D Lazzaro; M Price; M de Felice; R Di Lauro
Journal:  Development       Date:  1991-12       Impact factor: 6.868
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  12 in total

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3.  A zinc-dependent DNA-binding activity co-operates with cAMP-responsive-element-binding protein to activate the human thyroglobulin enhancer.

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Journal:  Biochem J       Date:  1997-04-15       Impact factor: 3.857

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Journal:  Thyroid       Date:  2014-01-23       Impact factor: 6.568

8.  Synergistic transcriptional activation of the thyrotropin receptor promoter by cyclic AMP-responsive-element-binding protein and thyroid transcription factor 1.

Authors:  A Saiardi; P Falasca; D Civitareale
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9.  Thyroid Hormone Indices in Computer Workers with Emphasis on the Role of Zinc Supplementation.

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Journal:  Open Access Maced J Med Sci       Date:  2016-03-15

10.  Selenium, Zinc, and Copper Status in Euthyroid Nodular Goiter: A Cross-Sectional Study.

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