Literature DB >> 7818266

Safe disposal of diisopropyl fluorophosphate (DFP).

G Lunn1, E B Sansone.   

Abstract

Diisopropyl fluorophosphate (DFP), a volatile highly toxic enzyme inhibitor, in buffer (pH 3, pH 5, pH 7, pH 9, pH 11, Hank's, Dulbecco's, PBS, TBE, and HEPES) or water (10 mM), in DMF solution (200 mM), and bulk quantities can be degraded by adding 1M NaOH. The DFP was completely degraded, as determined by enzymatic assay, and the final reaction mixtures were not mutagenic.

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Year:  1994        PMID: 7818266     DOI: 10.1007/bf02788550

Source DB:  PubMed          Journal:  Appl Biochem Biotechnol        ISSN: 0273-2289            Impact factor:   2.926


  15 in total

1.  A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin.

Authors:  B C HUMMEL
Journal:  Can J Biochem Physiol       Date:  1959-12

2.  Rate of Decomposition of GB in Seawater.

Authors:  J Epstein
Journal:  Science       Date:  1970-12-25       Impact factor: 47.728

3.  Aerial oxidation of hydrazines to nitrosamines.

Authors:  G Lunn; E B Sansone; A W Andrews
Journal:  Environ Mol Mutagen       Date:  1991       Impact factor: 3.216

4.  Platelet activating factor biosynthesis and degradation in rat glomeruli.

Authors:  A Zanglis; E A Lianos
Journal:  J Lab Clin Med       Date:  1987-09

5.  Regulation of newly synthesized acetylcholinesterase in muscle cultures treated with diisopropylfluorophosphate.

Authors:  B W Wilson; C R Walker
Journal:  Proc Natl Acad Sci U S A       Date:  1974-08       Impact factor: 11.205

6.  The stability of sarin and soman in dilute aqueous solutions and the catalytic effect of acetate ion.

Authors:  R I Ellin; W A Groff; A Kaminskis
Journal:  J Environ Sci Health B       Date:  1981       Impact factor: 1.990

7.  Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer.

Authors:  L B Schwartz; T R Bradford
Journal:  J Biol Chem       Date:  1986-06-05       Impact factor: 5.157

8.  Strain comparisons of DFP neurotoxicity in rats.

Authors:  C J Gordon; R C MacPhail
Journal:  J Toxicol Environ Health       Date:  1993-03

9.  Separation and spectral properties of diisopropylphosphate, the major decomposition product of isoflurophate.

Authors:  J A Ryan; W R McGaughran; C J Lindemann; A G Zacchei
Journal:  J Pharm Sci       Date:  1979-09       Impact factor: 3.534

10.  Purification and characterization of dog mastocytoma chymase: identification of an octapeptide conserved in chymotryptic leukocyte proteinases.

Authors:  G H Caughey; N F Viro; S C Lazarus; J A Nadel
Journal:  Biochim Biophys Acta       Date:  1988-01-29
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