Literature DB >> 7816803

Expression of the wild-type p53 antioncogene induces guanine nucleotide-dependent stem cell division kinetics.

J L Sherley1, P B Stadler, D R Johnson.   

Abstract

The predominant type of cell division in adult mammals is renewal growth. Renewing stem cells in somatic tissues undergo continuous asymmetric divisions. One new daughter cell retains the division potential of the original stem cell, while the other differentiates into a functional constituent of the tissue. Disruptions of this process lead to the development of human cancers. We show that through a guanine nucleotide-dependent mechanism, the p53 antioncogene can induce exponentially dividing cells to switch to an asymmetric stem cell growth pattern. This finding suggests that the observed high frequency of p53 mutations in human cancers reflects a critical function in the regulation of somatic renewal growth.

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Year:  1995        PMID： 7816803      PMCID： PMC42832          DOI： 10.1073/pnas.92.1.136

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53.

Authors:  L R Livingstone; A White; J Sprouse; E Livanos; T Jacks; T D Tlsty
Journal:  Cell       Date:  1992-09-18       Impact factor: 41.582

Review 2.  p53 function and dysfunction.

Authors:  B Vogelstein; K W Kinzler
Journal:  Cell       Date:  1992-08-21       Impact factor: 41.582

3.  Guanine nucleotide biosynthesis is regulated by the cellular p53 concentration.

Authors:  J L Sherley
Journal:  J Biol Chem       Date:  1991-12-25       Impact factor: 5.157

4.  Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours.

Authors:  L A Donehower; M Harvey; B L Slagle; M J McArthur; C A Montgomery; J S Butel; A Bradley
Journal:  Nature       Date:  1992-03-19       Impact factor: 49.962

5.  Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome.

Authors:  S Srivastava; Z Q Zou; K Pirollo; W Blattner; E H Chang
Journal:  Nature       Date:  1990 Dec 20-27       Impact factor: 49.962

Review 6.  The p53 tumour suppressor gene.

Authors:  A J Levine; J Momand; C A Finlay
Journal:  Nature       Date:  1991-06-06       Impact factor: 49.962

7.  Participation of p53 protein in the cellular response to DNA damage.

Authors:  M B Kastan; O Onyekwere; D Sidransky; B Vogelstein; R W Craig
Journal:  Cancer Res       Date:  1991-12-01       Impact factor: 12.701

8.  Detection of both mutant and wild-type p53 protein in normal skin fibroblasts and demonstration of a shared 'second hit' on p53 in diverse tumors from a cancer-prone family with Li-Fraumeni syndrome.

Authors:  S Srivastava; Y A Tong; K Devadas; Z Q Zou; V W Sykes; Y Chen; W A Blattner; K Pirollo; E H Chang
Journal:  Oncogene       Date:  1992-05       Impact factor: 9.867

9.  p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts.

Authors:  D M Harvey; A J Levine
Journal:  Genes Dev       Date:  1991-12       Impact factor: 11.361

10.  Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6.

Authors:  E Yonish-Rouach; D Resnitzky; J Lotem; L Sachs; A Kimchi; M Oren
Journal:  Nature       Date:  1991-07-25       Impact factor: 49.962
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  16 in total

Review 1.  In search of "stemness".

Authors:  Jingli Cai; Mark L Weiss; Mahendra S Rao
Journal:  Exp Hematol       Date:  2004-07       Impact factor: 3.084

2.  "Mesenchymal" stem cells in human bone marrow (skeletal stem cells): a critical discussion of their nature, identity, and significance in incurable skeletal disease.

Authors:  Paolo Bianco; Pamela Gehron Robey; Isabella Saggio; Mara Riminucci
Journal:  Hum Gene Ther       Date:  2010-09       Impact factor: 5.695

Review 3.  Molecular mechanisms of asymmetric divisions in mammary stem cells.

Authors:  Angela Santoro; Thalia Vlachou; Manuel Carminati; Pier Giuseppe Pelicci; Marina Mapelli
Journal:  EMBO Rep       Date:  2016-11-21       Impact factor: 8.807

4.  Sparse feature selection identifies H2A.Z as a novel, pattern-specific biomarker for asymmetrically self-renewing distributed stem cells.

Authors:  Yang Hoon Huh; Minsoo Noh; Frank R Burden; Jennifer C Chen; David A Winkler; James L Sherley
Journal:  Stem Cell Res       Date:  2015-01-06       Impact factor: 2.020

5.  Inosine-5'-monophosphate dehydrogenase is a rate-determining factor for p53-dependent growth regulation.

Authors:  Y Liu; S A Bohn; J L Sherley
Journal:  Mol Biol Cell       Date:  1998-01       Impact factor: 4.138

6.  Escaping the stem cell compartment: sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations.

Authors:  W Zhang; E Remenyik; D Zelterman; D E Brash; N M Wikonkal
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-13       Impact factor: 11.205

7.  Ultraviolet A within sunlight induces mutations in the epidermal basal layer of engineered human skin.

Authors:  Xiao Xuan Huang; Françoise Bernerd; Gary Mark Halliday
Journal:  Am J Pathol       Date:  2009-03-05       Impact factor: 4.307

8.  Higher 5-hydroxymethylcytosine identifies immortal DNA strand chromosomes in asymmetrically self-renewing distributed stem cells.

Authors:  Yang Hoon Huh; Justin Cohen; James L Sherley
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-30       Impact factor: 11.205

Review 9.  Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.

Authors:  Sara Sigismund; Stefano Confalonieri; Andrea Ciliberto; Simona Polo; Giorgio Scita; Pier Paolo Di Fiore
Journal:  Physiol Rev       Date:  2012-01       Impact factor: 37.312

10.  In vitro expansion of the mammary stem/progenitor cell population by xanthosine treatment.

Authors:  Ratan K Choudhary; Anthony V Capuco
Journal:  BMC Cell Biol       Date:  2012-06-14       Impact factor: 4.241
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