| Literature DB >> 7814234 |
B M Barrett1, A Sowell, E Gunter, M Wang.
Abstract
The association of antioxidant vitamins in serum and amniotic fluid with preterm rupture of fetal membrane (PROM) was examined. Amniotic fluid and venous blood specimens from 80 pregnant women with or without PROM were analyzed for ascorbic acid (ASA), alpha-tocopherol, retinol and beta-carotene concentrations. No differences in retinol and alpha-tocopherol in amniotic fluid or serum concentrations were found between the PROM and control groups. PROM and control subjects had similar serum ASA concentrations. However, PROM subjects had lower amniotic fluid ASA concentrations (p < 0.0001) and lower ratios of amniotic fluid ASA to serum ASA concentration than those of controls. Serum beta-carotene levels were lower in PROM group than control group (p = 0.025). The findings suggest that a low level of ASA in amniotic fluid but not serum appears to be an important determinant of PROM. beta-Carotene and ASA may act synergistically to prevent PROM in smokers.Entities:
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Year: 1994 PMID： 7814234
Source DB: PubMed Journal: Int J Vitam Nutr Res ISSN： 0300-9831 Impact factor: 1.784