Richa Sharma1, Sumita Mehta2. 1. 206, Kanchanjunga, Kaushambhi, Ghaziabad, Uttar Pradesh India. 2. Department of Obstetrics & Gynecology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, 110095 India.
Abstract
INTRODUCTION: Preterm premature rupture of membranes (PPROM) complicates 1-5 % of all pregnancies and is the major contributory factor for perinatal morbidity and mortality. Micronutrient deficiency (vitamin C) is associated with increased risk of PPROM. This study was conducted to establish the association between maternal plasma vitamin C concentration in women with PPROM and women without PPROM and to study the difference in maternal morbidity, neonatal morbidity, and mortality. METHODS: A prospective study was conducted where 40 women (20 in each study and control group) with singleton pregnancies between 28 and 37 weeks gestation were recruited. Women with anemia, diabetes, UTI, RTI, vaginal infection, bleeding, h/o PPROM in previous pregnancy, polyhydramnios, and smoker were excluded from the study. Maternal plasma vitamin C levels were measured. RESULTS: Ascorbic acid levels were low in women with PPROM 0.41 ± 0.08 versus 0.84 ± 0.19 mg/dl. There is a linear decline in plasma vitamin C levels as the pregnancy advances. Inverse relationship was observed between duration of rupture of membranes and vitamin C levels. There was a significant difference in maternal morbidity, neonatal morbidity, and mortality. CONCLUSION: Ascorbic acid concentration was low in women with PPROM. Thus, vitamin C supplementation should be made mandatory along with iron and calcium to antenatal women to avoid the complications of PPROM.
INTRODUCTION:Preterm premature rupture of membranes (PPROM) complicates 1-5 % of all pregnancies and is the major contributory factor for perinatal morbidity and mortality. Micronutrient deficiency (vitamin C) is associated with increased risk of PPROM. This study was conducted to establish the association between maternal plasma vitamin C concentration in women with PPROM and women without PPROM and to study the difference in maternal morbidity, neonatal morbidity, and mortality. METHODS: A prospective study was conducted where 40 women (20 in each study and control group) with singleton pregnancies between 28 and 37 weeks gestation were recruited. Women with anemia, diabetes, UTI, RTI, vaginal infection, bleeding, h/o PPROM in previous pregnancy, polyhydramnios, and smoker were excluded from the study. Maternal plasma vitamin C levels were measured. RESULTS:Ascorbic acid levels were low in women with PPROM 0.41 ± 0.08 versus 0.84 ± 0.19 mg/dl. There is a linear decline in plasma vitamin C levels as the pregnancy advances. Inverse relationship was observed between duration of rupture of membranes and vitamin C levels. There was a significant difference in maternal morbidity, neonatal morbidity, and mortality. CONCLUSION:Ascorbic acid concentration was low in women with PPROM. Thus, vitamin C supplementation should be made mandatory along with iron and calcium to antenatal women to avoid the complications of PPROM.
Authors: Esther Casanueva; Carmina Ripoll; Maricruz Tolentino; Rosa Maria Morales; Frania Pfeffer; Pablo Vilchis; Felipe Vadillo-Ortega Journal: Am J Clin Nutr Date: 2005-04 Impact factor: 7.045
Authors: Tadashi Yamashita; Ramon Emilio Daniel Roces; Cecilia Ladines-Llave; Maria Teresa Reyes Tuliao; Mary Wanjira Kamau; Chika Yamada; Yuko Tanaka; Kyoko Shimazawa; Saori Iwamoto; Hiroya Matsuo Journal: Int J Environ Res Public Health Date: 2021-11-23 Impact factor: 3.390