Literature DB >> 7811236

Hamster gastric inhibitory polypeptide receptor expressed in pancreatic islets and clonal insulin-secreting cells: its structure and functional properties.

K Yasuda1, N Inagaki, Y Yamada, A Kubota, S Seino, Y Seino.   

Abstract

We have isolated a cDNA encoding a gastric inhibitory polypeptide (GIP) receptor from a hamster insulinoma (HIT-T15) cDNA library. The hamster GIP receptor is a 462 amino acid protein having seven transmembrane segments. Expression of recombinant of hamster GIP receptors in Chinese hamster ovary (CHO) cells shows that it binds specifically to GIP with high affinity (IC50 = 9.6 nM) and is positively coupled to adenylate cyclase, but not to phospholipase C. RNA blot analysis reveals that a 3.8-kb GIP receptor mRNA is expressed at high levels in rat pancreatic islets as well as in HIT-T15 cells.

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Year:  1994        PMID： 7811236     DOI： 10.1006/bbrc.1994.2844

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

Review 1.  Dynamics of insulin secretion and the clinical implications for obesity and diabetes.

Authors:  Susumu Seino; Tadao Shibasaki; Kohtaro Minami
Journal:  J Clin Invest       Date:  2011-06-01       Impact factor: 14.808

2.  Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice.

Authors:  K Miyawaki; Y Yamada; H Yano; H Niwa; N Ban; Y Ihara; A Kubota; S Fujimoto; M Kajikawa; A Kuroe; K Tsuda; H Hashimoto; T Yamashita; T Jomori; F Tashiro; J Miyazaki; Y Seino
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-21       Impact factor: 11.205

Review 3.  The pathogenic role of the GIP/GIPR axis in human endocrine tumors: emerging clinical mechanisms beyond diabetes.

Authors:  Daniela Regazzo; Mattia Barbot; Carla Scaroni; Nora Albiger; Gianluca Occhi
Journal:  Rev Endocr Metab Disord       Date:  2020-03       Impact factor: 6.514

Review 4.  The role of incretins in glucose homeostasis and diabetes treatment.

Authors:  Wook Kim; Josephine M Egan
Journal:  Pharmacol Rev       Date:  2008-12-12       Impact factor: 25.468

5.  Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2.

Authors:  D G Munroe; A K Gupta; F Kooshesh; T B Vyas; G Rizkalla; H Wang; L Demchyshyn; Z J Yang; R K Kamboj; H Chen; K McCallum; M Sumner-Smith; D J Drucker; A Crivici
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-16       Impact factor: 11.205

Review 6.  Pancreatic beta-cell signaling: toward better understanding of diabetes and its treatment.

Authors:  Susumu Seino; Tadao Shibasaki; Kohtaro Minami
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2010       Impact factor: 3.493

Review 7.  GIP and GLP-1, the two incretin hormones: Similarities and differences.

Authors:  Yutaka Seino; Mitsuo Fukushima; Daisuke Yabe
Journal:  J Diabetes Investig       Date:  2010-04-22       Impact factor: 4.232

8.  Transcriptional analysis of apoptotic cerebellar granule neurons following rescue by gastric inhibitory polypeptide.

Authors:  Barbara Maino; Maria Teresa Ciotti; Pietro Calissano; Sebastiano Cavallaro
Journal:  Int J Mol Sci       Date:  2014-04-01       Impact factor: 5.923

Review 9.  Role of a Dual Glucose-Dependent Insulinotropic Peptide (GIP)/Glucagon-like Peptide-1 Receptor Agonist (Twincretin) in Glycemic Control: From Pathophysiology to Treatment.

Authors:  Maria Chiara Pelle; Michele Provenzano; Isabella Zaffina; Roberta Pujia; Federica Giofrè; Stefania Lucà; Michele Andreucci; Angela Sciacqua; Franco Arturi
Journal:  Life (Basel)       Date:  2021-12-25
  9 in total

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