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Literature DB >> 21633180

Dynamics of insulin secretion and the clinical implications for obesity and diabetes.

Susumu Seino¹, Tadao Shibasaki, Kohtaro Minami.

Abstract

Insulin secretion is a highly dynamic process regulated by various factors including nutrients, hormones, and neuronal inputs. The dynamics of insulin secretion can be studied at different levels: the single β cell, pancreatic islet, whole pancreas, and the intact organism. Studies have begun to analyze cellular and molecular mechanisms underlying dynamics of insulin secretion. This review focuses on our current understanding of the dynamics of insulin secretion in vitro and in vivo and discusses their clinical relevance.

Entities: Disease Gene

Mesh：

Substances：

Year: 2011 PMID： 21633180 PMCID： PMC3104758 DOI： 10.1172/JCI45680

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

119 in total

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Journal: J Clin Invest Date: 1988-02 Impact factor: 14.808

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Journal: Metabolism Date: 2009-05 Impact factor: 8.694

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Journal: N Engl J Med Date: 1988-05-12 Impact factor: 91.245

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Journal: Proc Natl Acad Sci U S A Date: 1999-05-11 Impact factor: 11.205

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Journal: Biochem Biophys Res Commun Date: 1994-12-30 Impact factor: 3.575

142 in total

Review 1. Role of phospholipase Cε in physiological phosphoinositide signaling networks.

Authors: Alan V Smrcka; Joan Heller Brown; George G Holz
Journal: Cell Signal Date: 2012-01-20 Impact factor: 4.315

2. SAD-A and AMPK kinases: the "yin and yang" regulators of mTORC1 signaling in pancreatic β cells.

Authors: Jia Nie; Xiao Han; Yuguang Shi
Journal: Cell Cycle Date: 2013-09-18 Impact factor: 4.534

3. A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils.

Authors: Yong Zhang; Wenwen Tang; Haifeng Zhang; Xiaofeng Niu; Yingke Xu; Jiasheng Zhang; Kun Gao; Weijun Pan; Titus J Boggon; Derek Toomre; Wang Min; Dianqing Wu
Journal: Dev Cell Date: 2013-10-28 Impact factor: 12.270

4. Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies.

Authors: Peter Hoboth; Andreas Müller; Anna Ivanova; Hassan Mziaut; Jaber Dehghany; Anke Sönmez; Martina Lachnit; Michael Meyer-Hermann; Yannis Kalaidzidis; Michele Solimena
Journal: Proc Natl Acad Sci U S A Date: 2015-02-02 Impact factor: 11.205

5. LIM-homeodomain transcription factor Isl-1 mediates kisspeptin's effect on insulin secretion in mice.

Authors: Juan Chen; Rui Fu; Yan Cui; Jirong Pan; Yushan Li; Xiaoxin Zhang; Sylvia M Evans; Sheng Cui; Jiali Liu
Journal: Mol Endocrinol Date: 2014-06-23

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Authors: Patrick M Misun; Burçak Yesildag; Felix Forschler; Aparna Neelakandhan; Nassim Rousset; Adelinn Biernath; Andreas Hierlemann; Olivier Frey
Journal: Adv Biosyst Date: 2020-01-29

7. Duodeno-jejunal bypass restores β-cell hypersecretion and islet hypertrophy in western diet obese rats.

Authors: Mariana Carla Mendes; Maria Lúcia Bonfleur; Rosane Aparecida Ribeiro; Camila Lubaczeuski; Ana Flavia Justino Fêo; Rodrigo Vargas; Everardo Magalhães Carneiro; Antonio Carlos Boschero; Allan Cezar Faria Araujo; Sandra Lucinei Balbo
Journal: Endocrine Date: 2018-03-19 Impact factor: 3.633