Literature DB >> 7811038

Pig kidney (LLC-PK1) cell membrane fluidity during exposure to gentamicin or tobramycin.

S J Kohlhepp1, L Hou, D N Gilbert.   

Abstract

The surface membrane properties of LLC-PK1 cells grown with and without various amounts of gentamicin or tobramycin for various lengths of time were determined by measuring the diffusion coefficient of N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)dipalmitoyl-L- alpha-phosphatidylethanolamine (NBD-PE) and the percentage of NBD-PE free to diffuse after photobleaching. One hour of exposure to tobramycin decreased the percentage that was free to diffuse. After 1 day or longer of exposure to either aminoglycoside the percentage that was free to diffuse returned to preexposure levels and the diffusion coefficient decreased.

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Year:  1994        PMID： 7811038      PMCID： PMC284703          DOI： 10.1128/AAC.38.9.2169

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

1.  Dynamics of fluorescence marker concentration as a probe of mobility.

Authors:  D E Koppel; D Axelrod; J Schlessinger; E L Elson; W W Webb
Journal:  Biophys J       Date:  1976-11       Impact factor: 4.033

2.  Gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts. Quantitative ultrastructural and biochemical study.

Authors:  G Aubert-Tulkens; F Van Hoof; P Tulkens
Journal:  Lab Invest       Date:  1979-04       Impact factor: 5.662

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Authors:  A Goffeau; G Aubert-Tulkens; F Van Hoff
Journal:  Arch Int Physiol Biochim       Date:  1978-05

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Authors:  J Yguerabide; J A Schmidt; E E Yguerabide
Journal:  Biophys J       Date:  1982-10       Impact factor: 4.033

5.  Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney.

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Journal:  Arch Otorhinolaryngol       Date:  1979

6.  Interactions of aminoglycoside antibiotics with negatively charged lipid layers. Biochemical and conformational studies.

Authors:  R Brasseur; G Laurent; J M Ruysschaert; P Tulkens
Journal:  Biochem Pharmacol       Date:  1984-02-15       Impact factor: 5.858

7.  Cytoskeleton as a target in menadione-induced oxidative stress in cultured mammalian cells: alterations underlying surface bleb formation.

Authors:  W Malorni; F Iosi; F Mirabelli; G Bellomo
Journal:  Chem Biol Interact       Date:  1991       Impact factor: 5.192

8.  Mechanism of aminoglycoside-induced lysosomal phospholipidosis: in vitro and in vivo studies with gentamicin and amikacin.

Authors:  G Laurent; M B Carlier; B Rollman; F Van Hoof; P Tulkens
Journal:  Biochem Pharmacol       Date:  1982-12-01       Impact factor: 5.858

9.  Alterations in renal cortical phospholipid content induced by gentamicin: time course, specificity, and subcellular localization.

Authors:  T C Knauss; J M Weinberg; H D Humes
Journal:  Am J Physiol       Date:  1983-05

10.  Aminoglycoside antibiotics inhibit lysosomal phospholipase A and C from rat liver in vitro.

Authors:  K Y Hostetler; L B Hall
Journal:  Biochim Biophys Acta       Date:  1982-03-12
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  1 in total

1.  Interaction of gentamicin with phosphatidylserine/phosphatidylcholine mixtures in adsorption monolayers and thin liquid films: morphology and thermodynamic properties.

Authors:  Georgi D Georgiev; Georgi As Georgiev; Z Lalchev
Journal:  Eur Biophys J       Date:  2010-03-04       Impact factor: 1.733
  1 in total

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