Literature DB >> 226045

Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney.

J Schacht.   

Abstract

Affinity chromatography was used to isolate aminoglycoside receptors from inner ear tissues and kidney. Neomycin was immobilized on glass beads and served as the stationary phase in column chromatography. Fractionation of an organic tissue extract on this matrix demonstrated two components with high affinity for neomycin: phohphatidyl inositol phosphate and phosphatidyl inositol diphosphate. The toxicity of aminoglycosides is explained on the basis of a drug-interaction with these lipids.

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Year:  1979        PMID： 226045     DOI： 10.1007/bf00455236

Source DB:  PubMed          Journal:  Arch Otorhinolaryngol        ISSN： 0302-9530


  13 in total

1.  ION EXCHANGE CHROMATOGRAPHY OF INTACT BRAIN PHOSPHOINOSITIDES ON DIETHYLAMINOETHYL CELLULOSE BY GRADIENT SALT ELUTION IN A MIXED SOLVENT SYSTEM.

Authors:  H S HENDRICKSON; C E BALLOU
Journal:  J Biol Chem       Date:  1964-05       Impact factor: 5.157

2.  Effect of neomycin on phosphoinositide labelling and calcium binding in guinea-pig inner ear tissues in vivo and in vitro.

Authors:  A Orsulakova; E Stockhorst; J Schacht
Journal:  J Neurochem       Date:  1976-02       Impact factor: 5.372

3.  Inhibitory effects of kanamycin on glycolysis in cochlea and kidney-possible involvement in the formation of oto- and nephrotoxicities.

Authors:  M Tachibana; O Mizukoshi; K Kuriyama
Journal:  Biochem Pharmacol       Date:  1976-10-15       Impact factor: 5.858

4.  Purification of polyphosphoinositides by chromatography on immobilized neomycin.

Authors:  J Schacht
Journal:  J Lipid Res       Date:  1978-11       Impact factor: 5.922

5.  Radioactive labeling of phospholipids and proteins by cochlear perfusion in the guinea pig and the effect of neomycin.

Authors:  E Stockhorst; J Schacht
Journal:  Acta Otolaryngol       Date:  1977 May-Jun       Impact factor: 1.494

6.  Improved conditions for the preservation and extraction of polyphosphoinositides.

Authors:  G Hauser; J Eichberg
Journal:  Biochim Biophys Acta       Date:  1973-11-29

7.  Physiological significance of polyphosphoinositides in brain.

Authors:  M Kai; J N Hawthorne
Journal:  Ann N Y Acad Sci       Date:  1969-10-17       Impact factor: 5.691

8.  Interactions of neomycin and calcium in synaptosomal membranes and polyphosphoinostide monolayers.

Authors:  S Lodhi; N D Weiner; J Schacht
Journal:  Biochim Biophys Acta       Date:  1976-04-05

9.  Gentamicin-induced changes in RNA content in sensory and ganglionic cells in the hearing organ of the lizard Calotes versicolor. A cytochemical and morphological investigation.

Authors:  J Jarlstedt; D Bagger-Sjöbäck
Journal:  Acta Otolaryngol       Date:  1977 Nov-Dec       Impact factor: 1.494

10.  Inhibition by neomycin of polyphosphoinositide turnover in subcellular fractions of guinea-pig cerebral cortex in vitro.

Authors:  J Schacht
Journal:  J Neurochem       Date:  1976-11       Impact factor: 5.372
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  25 in total

1.  Identification of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins by neomycin extraction.

Authors:  Aurélia E Lewis; Lilly Sommer; Magnus Ø Arntzen; Yvan Strahm; Nicholas A Morrice; Nullin Divecha; Clive S D'Santos
Journal:  Mol Cell Proteomics       Date:  2010-11-03       Impact factor: 5.911

2.  Cytoplasmic and intra-nuclear binding of gentamicin does not require endocytosis.

Authors:  Sigrid E Myrdal; Katherine C Johnson; Peter S Steyger
Journal:  Hear Res       Date:  2005-06       Impact factor: 3.208

3.  Polymyxin-B-binding sites in the cochlea as demonstrated by polymyxin-B/gold labeling.

Authors:  M Tachibana; H Morioka; M Machino; O Mizukoshi
Journal:  Histochemistry       Date:  1986

Review 4.  New developments in aminoglycoside therapy and ototoxicity.

Authors:  Jing Xie; Andra E Talaska; Jochen Schacht
Journal:  Hear Res       Date:  2011-05-27       Impact factor: 3.208

5.  TRPV1 regulators mediate gentamicin penetration of cultured kidney cells.

Authors:  Sigrid E Myrdal; Peter S Steyger
Journal:  Hear Res       Date:  2005-06       Impact factor: 3.208

6.  Binding sites of an aminoglycoside in the cochlea examined by immunocytochemistry.

Authors:  M Tachibana; H Morioka; M Machino; O Mizukoshi
Journal:  Histochemistry       Date:  1985

7.  Biochemical studies on the embryonic development of the mammalian inner ear in organ culture.

Authors:  M Anniko; H Nordemar; M L Spångberg; J Schacht
Journal:  Arch Otorhinolaryngol       Date:  1981

Review 8.  Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention.

Authors:  Jochen Schacht; Andra E Talaska; Leonard P Rybak
Journal:  Anat Rec (Hoboken)       Date:  2012-10-08       Impact factor: 2.064

9.  Calcium is a competitive inhibitor of gentamicin-renal membrane binding interactions and dietary calcium supplementation protects against gentamicin nephrotoxicity.

Authors:  H D Humes; M Sastrasinh; J M Weinberg
Journal:  J Clin Invest       Date:  1984-01       Impact factor: 14.808

10.  Protective effect of piperacillin against nephrotoxicity of cephaloridine and gentamicin in animals.

Authors:  T Hayashi; Y Watanabe; K Kumano; R Kitayama; T Yasuda; I Saikawa; J Katahira; T Kumada; K Shimizu
Journal:  Antimicrob Agents Chemother       Date:  1988-06       Impact factor: 5.191
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